Evidence map›Paper›PMID 34476719›Full record

ArticleCulture, medicine and psychiatry2022

Ancient Roots of Today's Emerging Renaissance in Psychedelic Medicine.

Daniel R George, Ryan Hanson, Darryl Wilkinson, Albert Garcia-Romeu

Open access · bronzeAbstract readEditorial
In one paragraph

Article in Culture, medicine and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. 4-Hy-droxy-IUCrData · 2025
    Article
  6. Article
  7. Psychedelics: Safety and Efficacy.International journal of environmental research and public health · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. An Occupational Perspective on Psychedelic Therapy: A Scoping Review.Canadian journal of occupational therapy. Revue canadienne d'ergotherapie · 2024
    Article
  13. Synthetic surprise as the foundation of the psychedelic experience.Neuroscience and biobehavioral reviews · 2024
    Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Daniel R GeorgeDepartment of Humanities, Penn State Milton S Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA. Dgeorge1@pennstatehealth.psu.edu.ORCID http://orcid.org/0000-0002-6153-6648
Ryan HansonAnesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
Darryl WilkinsonDepartment of Religion, Dartmouth University, Hanover, NH, USA.
Albert Garcia-RomeuCenter for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Cleveland Clinic · USDartmouth College · USJohns Hopkins University · USPenn State Milton S. Hershey Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An international ban on psychedelics initiated by the United Nations' Convention on Psychotropic Substances in 1971 restricted the clinical use of these ancient psychoactive substances. Yet, in an era marked by rising mental health concerns and a growing "Deaths of Despair" epidemic (i.e., excess mortality and morbidity from suicide, drug overdose, and alcoholism), the structured psychedelic use that has long been a part of ritual healing experiences for human societies is slowly regaining credibility in Western medicine for its potential to treat various mental health conditions. We use a historical lens to examine the use of psychedelic therapies over time, translate ancient lessons to contemporary clinical and research practice, and interrogate the practical and ethical questions researchers must grapple with before they can enter mainstream medicine. Given the COVID-19 pandemic and its contributions to the global mental health burden, we also reflect on how psychedelic therapy might serve as a tool for medicine in the aftermath of collective trauma. Ultimately, it is argued that a "psychedelic renaissance" anchored in the lessons of antiquity can potentially help shift healthcare systems-and perhaps the broader society-towards practices that are more humane, attentive to underlying causes of distress, and supportive of human flourishing.

Indexed as

COVID-19HallucinogensMental DisordersHumansMental HealthPandemicsHallucinogensClinical medicineEthicsHealth humanitiesMental healthPsychedelic medicine

Identifiers

PMID34476719
PMCPMC8412860
OpenAlexW3198659533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.