Evidence map›Paper›PMID 34476718›Full record

ReviewMetabolic brain disease2022

Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders.

Tooran Nayeri, Shahabeddin Sarvi, Ahmad Daryani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

  1. A review onParasite epidemiology and control · 2026
    Review
  2. Article
  3. From cats to cortex:Frontiers in psychiatry · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Effects of diet and ovariectomy onBrain communications · 2025
    Article
  10. Seroprevalence and Risk Factors forResearch and reports in tropical medicine · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Ivermectin modulated cerebral γ-aminobutyric acid (GABA) and reduced the number of chronicJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023
    Article
  17. Review
  18. Behavioral and Neuropathological Changes AfterFrontiers in cellular and infection microbiology · 2022
    Article
  19. ArePeerJ · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tooran NayeriToxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Shahabeddin SarviToxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Ahmad DaryaniToxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran. daryanii@yahoo.com.
Mazandaran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common form of the disease caused by Toxoplasma gondii (T. gondii) is latent toxoplasmosis due to the formation of tissue cysts in various organs, such as the brain. Latent toxoplasmosis is probably a risk factor in the development of some neuropsychiatric disorders. Behavioral changes after infection are caused by the host immune response, manipulation by the parasite, central nervous system (CNS) inflammation, as well as changes in hormonal and neuromodulator relationships. The present review focused on the exact mechanisms of T. gondii effect on the alteration of behavior and neurotransmitter levels, their catabolites and metabolites, as well as the interaction between immune responses and this parasite in the etiopathogenesis of psychiatric disorders. The dysfunction of neurotransmitters in the neural transmission is associated with several neuropsychiatric disorders. However, further intensive studies are required to determine the effect of this parasite on altering the level of neurotransmitters and the role of neurotransmitters in the etiology of host behavioral changes.

Indexed as

Mental DisordersToxoplasmaToxoplasmosisBrainHumansNeurotransmitter AgentsNeurotransmitter AgentsToxoplasma gondii. Neurotransmitter. Psychiatric disorders. Cytokine

Identifiers

PMID34476718
OpenAlexW3198021941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.