ArticleEnvironmental science and pollution research international2022
Associations between ambient heat exposure early in pregnancy and risk of congenital heart defects: a large population-based study.
Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Impact of exposure to extreme heat events during pregnancy on the incidence of congenital heart disease in offspring: a meta-analysis.BMJ paediatrics open · 2024Pooled it
- [Association between periconception maternal cold and heat exposure and the risk of congenital heart disease in offspring in China].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Association between climate change awareness and psychological distress among Turkish pregnant women: A cross-sectional study.Medicine · 2026Article
- Understanding Heat Exposure Risks and Adaptation Behaviors Among Elderly Asian Communities in New York City.Urban climate · 2025Article
- Article
- Climate change and sexual and reproductive health and rights research in low-income and middle-income countries: a scoping review.BMJ public health · 2024Article
- Prediction of congenital heart disease for newborns: comparative analysis of Holt-Winters exponential smoothing and autoregressive integrated moving average models.BMC medical research methodology · 2022Article
- Impact of extreme heat and heatwaves on children's health: A scoping review.The journal of climate change and healthReview
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some epidemiological studies have confirmed the association between environmental factors and congenital heart defects (CHD). While the possibility that maternal ambient heat exposures are related to CHD has received little attention. Our study aims to investigate the association between maternal ambient extreme heat exposure early in pregnancy and the risk of CHD in offspring in China. We conducted a retrospective cohort study of 1,918,105 fetuses between 2 and 8 weeks after gestation from May to October in Guangdong, China, 2015-2019. The main heat exposure was defined as extreme heat events (EHE) by using the 90th (EHE90) or 95th (EHE95) percentile of the daily maximum temperature. For each EHE definition, we further defined four indicators: having EHE or not, frequency, duration, and cumulative days. We used the log-binomial regression models to calculate the prevalence ratios (PR) of CHD with 95% confidence intervals (CI) for the associations between CHD and EHE, adjusted for potentially confounding covariates. There are 1,918,105 infants included in the study, of which 9588 had CHD, with a prevalence rate of 499.9 per 100,000 (95% CI: 489.9, 509.8). We found that all EHE indicators were positively associated with the increased risks of overall CHD, some CHD classes (congenital malformations of cardiac septa, congenital malformations of great arteries, and congenital malformations of great arteries), and some CHD subtypes (atrial septal defect and patent ductus arteriosus). In addition, the PR yielded higher estimates when exposing to EHE95. For instance, the risk of suffering congenital malformations of great arteries was 1.548 (95% CI: 1.401, 1.712) for EHE90 exposure and 1.723 (95% CI: 1.565, 1.898) for EHE95 exposure, respectively. Our study demonstrated that EHE during 2-8 weeks postconception was associated with overall CHD in offspring, particularly atrial septal defects and patent ductus arteriosus. The associations strengthened with the extent and cumulative days of maternal exposure to EHE.
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