Evidence map›Paper›PMID 34476688›Full record

ArticleEnvironmental science and pollution research international2022

Ameliorative effect of ethoxylated chalcone-based MAO-B inhibitor on behavioural predictors of haloperidol-induced Parkinsonism in mice: evidence of its antioxidative role against Parkinson's diseases.

Naseer Maliyakkal, Uzma Saleem, Fareeha Anwar, Muhammad Ajmal Shah, Bashir Ahmad, Filzah Umer, Mohammad Ali Abdullah Almoyad, Della Grace Thomas Parambi, Asmy Appadath Beeran, Lekshmi R Nath and 2 more

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 5 countries.

Naseer MaliyakkalDepartment of Basic Medical Sciences, College of Applied Medical Sciences in Khamis Mushayt, King Khalid University, Abha, Saudi Arabia. nkassim@kku.edu.sa.ORCID http://orcid.org/0000-0001-6682-3876
Uzma SaleemDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Pakistan. uzma95@gmail.com.
Fareeha AnwarRiphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, 54000, Pakistan.
Muhammad Ajmal ShahDepartment of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Bashir AhmadRiphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, 54000, Pakistan.
Filzah UmerRiphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, 54000, Pakistan.
Mohammad Ali Abdullah AlmoyadDepartment of Basic Medical Sciences, College of Applied Medical Sciences in Khamis Mushayt, King Khalid University, Abha, Saudi Arabia.
Della Grace Thomas ParambiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Al Jouf-2014, Sakaka, Saudi Arabia.
Asmy Appadath BeeranManipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID http://orcid.org/0000-0002-2617-1735
Lekshmi R NathDepartment of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India.
Lotfi AleyaLaboratoire Chrono-Environnement, CNRS6249, Universite de Bourgogne Franche-Comte, Besancon, France.
Bijo MathewDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India. bijomathew@aims.amrita.edu.ORCID http://orcid.org/0000-0002-6658-4497
Riphah International University · PKGovernment College University, Faisalabad · PKKing Khalid University · SAAims Community College · USAmrita Vishwa Vidyapeetham · INCentre National de la Recherche Scientifique · FRJouf University · SAManipal Academy of Higher Education · IN

Funding

Female Center for Scientific and Medical Colleges, King Saud University RGP-159-42.
6 · The paper itself

Abstract

Parkinson's disease is a progressive neurodegenerative disorder that affects mostly elderly people above the age of 60. Previously, we have reported that the ethoxylated chalcone derivative (E)-1-(4-ethoxyphenyl)-3-(fluorophenyl)prop-2-en-1-one (E7) showed potent, reversible, and competitive MAO-B inhibition with an IC

Indexed as

ChalconesParkinsonian DisordersAnimalsAntioxidantsHaloperidolMiceMonoamine OxidaseMonoamine Oxidase InhibitorsAntioxidantsChalconesHaloperidolMonoamine OxidaseMonoamine Oxidase InhibitorsCatalepsyChalconeDopamineHaloperidol-induced animal modelLocomotionMAO-BNoradrenalineSerotonin

Identifiers

PMID34476688
OpenAlexW3198420760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.