Evidence map›Paper›PMID 34476674›Full record

ArticleMolecular neurobiology2021

Association Between Adenosine A

Daniela Madeira, Liliana Dias, Patrícia Santos, Rodrigo A Cunha, Paula M Canas, Paula Agostinho

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Astrocytic KFrontiers in aging neuroscience · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Feedback facilitation by adenosine APurinergic signalling · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Connexins Control Glial Inflammation in Various Neurological Diseases.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Review
  17. Article
  18. The Potential Role of Connexins in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2023
    Review
  19. AFrontiers in immunology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniela MadeiraFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.ORCID http://orcid.org/0000-0002-6027-5407
Liliana DiasFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.
Patrícia SantosCenter for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.
Rodrigo A CunhaFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal.ORCID http://orcid.org/0000-0003-2550-6422
Paula M CanasCenter for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.
Paula AgostinhoFaculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal. pagostinho@fmed.uc.pt.ORCID http://orcid.org/0000-0001-5523-4945
University of Coimbra · PT

Funding

Centro 2020 CENTRO-01-0145-FEDER-000008:BrainHealth2020 and CENTRO-01-0246-FEDER-000010fundação para a ciência e a tecnologia SFRH/BD/139334/2018fundação para a ciência e a tecnologia SFRH/BD/147159/2019Fundação para a Ciência e a Tecnologia POCI-01-0145-FEDER-031274"la Caixa" Foundation HP17/00523
6 · The paper itself

Abstract

Increasing evidence implicates astrocytes and the associated purinergic modulation in Alzheimer's disease (AD), characterized by cognitive deficits involving the extracellular amyloid-β peptides (Aβ) accumulation. Aβ can affect astrocytic gliotransmitters release, namely ATP, which is rapidly metabolized into adenosine by ecto-5'-nucleotidase, CD73, resulting in adenosine A

Indexed as

Adenosine TriphosphateAmyloid beta-PeptidesAnimalsAstrocytesConnexin 43PhosphorylationRatsRats, WistarReceptor, Adenosine A2AAdenosine TriphosphateAmyloid beta-PeptidesConnexin 43Receptor, Adenosine A2AAdenosine A2A receptorsAmyloid-βAstrocytesATPCD73Connexin 43Hemichannels

Identifiers

PMID34476674
OpenAlexW3196350659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.