Evidence map›Paper›PMID 34476593›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Association between the circulating superoxide dismutase and obstructive sleep apnea: a meta-analysis.

Zongsheng Tian, Hongying Sun, Jing Kang, Zhuangzhuang Mu, Jianmin Liang, Mingxian Li

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Is there an OAHI or OSleep & breathing = Schlaf & Atmung · 2024
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zongsheng TianDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China.
Hongying SunDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China.
Jing KangDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China.
Zhuangzhuang MuDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China.
Jianmin LiangDepartment of Pediatric Neurology, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China. liangjm@jlu.edu.cn.
Mingxian LiDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China. mingxian@jlu.edu.cn.ORCID http://orcid.org/0000-0002-3433-9147
Jilin University · CN

Funding

national natural science foundation of china 81670080
6 · The paper itself

Abstract

purposeAlthough it has been reported that superoxide dismutase (SOD) is related to obstructive sleep apnea (OSA), the results are controversial. In addition, the effects of the continuous positive airway pressure (CPAP) treatment on SOD levels are also inconsistent. The primary purpose of the present meta-analysis is to determine the relationship between the circulating SOD levels and OSA.

methodsThe studies included in this meta-analysis were selected from the PubMed, Embase, Cochrane Library, and Scopus databases. Two researchers independently reviewed the studies. Data analysis was performed using Stata 15.1. The overall effects were measured using the standardized mean difference (SMD) with a 95% confidence interval (CI). A random-effects model or a fixed-effects model was used, depending on the heterogeneity of the studies.

resultsA total of 14 studies were included, comprising 1240 patients and 457 controls. The results showed that the circulating SOD levels of the patients with OSA were significantly lower than that of the control group (SMD = - 1.645, 95% CI = - 2.279 to - 1.011, P < 0.001). We also studied changes in the circulating SOD levels in patients with OSA after the CPAP treatment. No significant difference was observed in the circulating SOD levels after the CPAP treatment (SMD = - 0.028, 95% CI = - 0.218 to 0.162, P = 0.772).

conclusionThe results suggested that patients with OSA have reduced levels of SOD and were related to disease severity. The results also indicated that circulating SOD levels may be a reliable marker for detecting systemic oxidative stress in patients with OSA. However, the circulating SOD levels were not affected by the short-term (4-12 weeks) CPAP treatment. Therefore, further large-scale, well-designed randomized controlled trials with a longer CPAP therapy (more than 6 months preferably) and good adherence to the treatment are needed to investigate this issue.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveBiomarkersHumansImmunotherapySuperoxide DismutaseBiomarkersSuperoxide DismutaseContinuous positive airway pressureObstructive sleep apneaOxidative stressSuperoxide dismutase

Identifiers

PMID34476593
OpenAlexW3198101712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.