Evidence map›Paper›PMID 34476512›Full record

ArticleNeuroradiology2022

Value of infarct location in the prediction of functional outcome in patients with an anterior large vessel occlusion: results from the HERMES study.

Manon L Tolhuisen, Marielle Ernst, Anne M M Boers, Scott Brown, Ludo F M Beenen, Francis Guillemin, Yvo B W E M Roos, Jeffrey L Saver, Robert van Oostenbrugge, Andrew M Demchuck and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Infarct density defined by ADC threshold is associated with long-term functional outcome after endovascular thrombectomy.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Manon L TolhuisenDepartment of Biomedical Engineering and Physics, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands. m.l.tolhuisen@amsterdamumc.nl.
Marielle ErnstDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
Anne M M BoersNico.Lab, www.nico-lab.com, Amsterdam, The Netherlands.
Scott BrownAltair Biostatistics, St Louis Park, MN, USA.
Ludo F M BeenenDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
Francis GuilleminCIC-Epidémiologie Clinique, 1433, Inserm, CHRU, Université de Lorraine, Nancy, France.
Yvo B W E M RoosDepartment of Neurology, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
Jeffrey L SaverDepartment of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Robert van OostenbruggeDepartment of Neurology, Maastricht UMC, Maastricht, The Netherlands.
Andrew M DemchuckDepartment of Clinical Neurosciences, Department of Radiology and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Wim van ZwamDepartment of Radiology, Maastricht UMC, Maastricht, The Netherlands.
Tudor G JovinDepartment of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Olvert A BerkhemerDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
Keith W MuirInstitute of Neuroscience and Psychology, University of Glasgow, University Avenue, Glasgow, UK.
Serge BracardCIC-Epidémiologie Clinique, 1433, Inserm, CHRU, Université de Lorraine, Nancy, France.
Bruce C V CampbellDepartment of Medicine, University of Melbourne, Parkville, Victoria, Australia.
Aad van der LugtInstitute of Neuroscience and Psychology, University of Glasgow, University Avenue, Glasgow, UK.
Phill WhiteTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Michael D HillDepartment of Clinical Neurosciences, Department of Radiology and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Diederik W J DippelDepartment of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Peter J MitchellDepartment of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Mayank GoyalDepartment of Clinical Neurosciences, Department of Radiology and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Matthan W A CaanDepartment of Biomedical Engineering and Physics, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
Henk A MarqueringDepartment of Biomedical Engineering and Physics, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
Charles B L M MajoieDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
HERMES collaborators

Funding

Medical Research Council MR/N003403/1
6 · The paper itself

Abstract

purposeFollow-up infarct volume (FIV) is moderately associated with functional outcome. We hypothesized that accounting for infarct location would strengthen the association of FIV with functional outcome.

methodsWe included 252 patients from the HERMES collaboration with follow-up diffusion weighted imaging. Patients received endovascular treatment combined with best medical management (n = 52%) versus best medical management alone (n = 48%). FIV was quantified in low, moderate and high modified Rankin Scale (mRS)-relevant regions. We used binary logistic regression to study the relation between the total, high, moderate or low mRS-relevant FIVs and favorable outcome (mRS < 2) after 90 days. The strength of association was evaluated using the c-statistic.

resultsSmall lesions only occupied high mRS-relevant brain regions. Lesions additionally occupied lower mRS-relevant brain regions if FIV expanded. Higher FIV was associated with a higher risk of unfavorable outcome, as were volumes of tissue with low, moderate and high mRS relevance. In multivariable modeling, only the volume of high mRS-relevant infarct was significantly associated with favorable outcome. The c-statistic was highest (0.76) for the models that included high mRS-relevant FIV or the combination of high, moderate and low mRS-relevant FIV but was not significantly different from the model that included only total FIV (0.75).

conclusionThis study confirms the association of FIV and unfavorable functional outcome but showed no strengthened association if lesion location was taken into account.

Indexed as

Brain IschemiaStrokeBrainCerebral InfarctionDiffusion Magnetic Resonance ImagingHumansRetrospective StudiesTreatment OutcomeAcute ischemic strokeDiffusion weighted imagingFollow-up infarct locationFunctional outcome

Identifiers

PMID34476512
PMCPMC8850210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.