Evidence map›Paper›PMID 34476399›Full record

ArticleACS applied polymer materials2021

Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillers.

Ravi Sinha, Alberto Sanchez, Maria Camara-Torres, Iñigo Calderon Uriszar-Aldaca, Andrea Roberto Calore, Jules Harings, Ambra Gambardella, Lucia Ciccarelli, Veronica Vanzanella, Michele Sisani and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in ACS applied polymer materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 4 countries.

Ravi SinhaMERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht 6229 ER, The Netherlands.
Alberto SanchezTECNALIA, Basque Research and Technology Alliance (BRTA), Mikeletegi 2, San Sebastián 20009, Spain.
Maria Camara-TorresMERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht 6229 ER, The Netherlands.
Iñigo Calderon Uriszar-AldacaTECNALIA, Basque Research and Technology Alliance (BRTA), Mikeletegi 2, San Sebastián 20009, Spain.
Andrea Roberto CaloreMERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht 6229 ER, The Netherlands.
Jules HaringsBiobased Materials, Sciences, Chemelot Center, Geleen 6167 RD, The Netherlands.
Ambra GambardellaUniversity of Naples Federico II, Naples 80125, Italy.
Lucia CiccarelliUniversity of Naples Federico II, Naples 80125, Italy.
Veronica VanzanellaUniversity of Naples Federico II, Naples 80125, Italy.
Michele SisaniProlabin & Tefarm S.r.l., Perugia 06134, Italy.
Marco ScattoNadir S.r.l., Mestre, Venice 30172, Italy.
Rune WendelboAbalonyx AS, Oslo 0373, Norway.
Sergio PerezTECNALIA, Basque Research and Technology Alliance (BRTA), Mikeletegi 2, San Sebastián 20009, Spain.
Sara VillanuevaTECNALIA, Basque Research and Technology Alliance (BRTA), Mikeletegi 2, San Sebastián 20009, Spain.
Amaia MatanzaCentro de Fisica de Materiales (CSIC, UPV/EHU), Materials Physics Center (MPC), San Sebastián 20018, Spain.
Alessandro PatelliDepartment of Physics and Astronomy, Padova University, Padova 35131, Italy.ORCID https://orcid.org/0000-0001-7662-4352
Nino GrizzutiUniversity of Naples Federico II, Naples 80125, Italy.
Carlos MotaMERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht 6229 ER, The Netherlands.ORCID https://orcid.org/0000-0001-5935-6245
Lorenzo MoroniMERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht 6229 ER, The Netherlands.ORCID https://orcid.org/0000-0003-1298-6025
Maastricht University · NLTecnalia · ESUniversity of Naples Federico II · ITAbalonyx (Norway) · NOLeonardo (Italy) · ITMaterial Physics Center · ESUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thermoplastic polymer-filler composites are excellent materials for bone tissue engineering (TE) scaffolds, combining the functionality of fillers with suitable load-bearing ability, biodegradability, and additive manufacturing (AM) compatibility of the polymer. Two key determinants of their utility are their rheological behavior in the molten state, determining AM processability and their mechanical load-bearing properties. We report here the characterization of both these physical properties for four bone TE relevant composite formulations with poly(ethylene oxide terephthalate)/poly(butylene terephthalate (PEOT/PBT) as a base polymer, which is often used to fabricate TE scaffolds. The fillers used were reduced graphene oxide (rGO), hydroxyapatite (HA), gentamicin intercalated in zirconium phosphate (ZrP-GTM) and ciprofloxacin intercalated in MgAl layered double hydroxide (MgAl-CFX). The rheological assessment showed that generally the viscous behavior dominated the elastic behavior (

Identifiers

PMID34476399
PMCPMC8397295
OpenAlexW3193909892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.