Evidence map›Paper›PMID 34476332›Full record

ArticleJCO precision oncology2021

Characterization of Non-Small-Cell Lung Cancers With MET Exon 14 Skipping Alterations Detected in Tissue or Liquid: Clinicogenomics and Real-World Treatment Patterns.

Jessica K Lee, Russell Madison, Anthony Classon, Ole Gjoerup, Mark Rosenzweig, Garrett M Frampton, Brian M Alexander, Geoffrey R Oxnard, Jeffrey M Venstrom, Mark M Awad and 1 more

Open access · hybridAbstract read
In one paragraph

Article in JCO precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. LINE-1 retrotransposition is a recurrent cause ofbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Improvement of Diagnostics in NSCLC Patients withInternational journal of molecular sciences · 2025
    Article
  9. Review
  10. First-Line MET Tyrosine Kinase Inhibitors versus Immunotherapy ± Chemotherapy for Patients with MET Exon 14 Skipping Mutant Metastatic NSCLC.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  11. Review
  12. Article
  13. Round-Robin Comparison of RET Rearrangement Detection in ctDNA: A Novel Method for Limited Clinical Samples.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Retrospective Analysis to Optimize the Detection ofDiagnostics (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jessica K LeeFoundation Medicine Inc, Cambridge, MA.
Russell MadisonFoundation Medicine Inc, Cambridge, MA.
Anthony ClassonFoundation Medicine Inc, Cambridge, MA.
Ole GjoerupFoundation Medicine Inc, Cambridge, MA.
Mark RosenzweigFoundation Medicine Inc, Cambridge, MA.
Garrett M FramptonFoundation Medicine Inc, Cambridge, MA.
Brian M AlexanderFoundation Medicine Inc, Cambridge, MA.
Geoffrey R OxnardFoundation Medicine Inc, Cambridge, MA.
Jeffrey M VenstromFoundation Medicine Inc, Cambridge, MA.
Mark M AwadLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.
Alexa B SchrockFoundation Medicine Inc, Cambridge, MA.
Foundation Medicine (United States)Dana-Farber Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose

methodsHybrid capture-based comprehensive genomic profiling (CGP) was performed on samples from 69,219 patients with NSCLC. For treatment patterns and outcomes analysis, patients with advanced

resultsA total of 1,592 patients with NSCLC (2.3%) were identified with 1,599

conclusionDiverse

Indexed as

AgedAged, 80 and overCarcinoma, Non-Small-Cell LungFemaleHumansMaleMiddle AgedMutationProto-Oncogene Proteins c-metMET protein, humanProto-Oncogene Proteins c-met

Identifiers

PMID34476332
PMCPMC8407654
OpenAlexW3193331733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.