Evidence map›Paper›PMID 34476331›Full record

ArticleJCO precision oncology2021

Retrospective Case Series Analysis of

Andrew Hendifar, Edik M Blais, Brian Wolpin, Vivek Subbiah, Eric Collisson, Isha Singh, Timothy Cannon, Kenna Shaw, Emanuel F Petricoin, Samuel Klempner and 4 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in JCO precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Metastatic pancreatic cancer with activatingWorld journal of clinical cases · 2025
    Article
  6. Observational
  7. Review
  8. Article
  9. Review
  10. Fusion genes in pancreatic tumors.Trends in cancer · 2024
    Review
  11. Review
  12. Chemotherapy-free treatment targeting fusions and driver mutations inTherapeutic advances in medical oncology · 2024
    Article
  13. Review
  14. Article
  15. BRAFScience advances · 2023
    Article
  16. Review
  17. Review
  18. Article
  19. The role of molecular testing in pancreatic cancer.Therapeutic advances in gastroenterology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Andrew HendifarCedars-Sinai Medical Center, Los Angeles, CA.
Edik M BlaisPerthera, Inc, McLean, VA.
Brian WolpinDana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Vivek SubbiahThe University of Texas MD Anderson Cancer Center, Houston, TX.
Eric CollissonHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
Isha SinghMemorial Sloan Kettering Cancer Center, New York, NY.
Timothy CannonInova Schar Cancer Institute, Fairfax, VA.
Kenna ShawThe University of Texas MD Anderson Cancer Center, Houston, TX.
Emanuel F PetricoinGeorge Mason University, Perthera, Inc, Fairfax, VA.
Samuel KlempnerMassachusetts General Hospital, Harvard Medical School, Boston, MA.
Emily LyonsPancreatic Cancer Action Network, Manhattan Beach, CA.
Andrea Wang-GillamWashington University School of Medicine, St Louis, MO.
Michael J PishvaianJohns Hopkins University School of Medicine, Perthera Inc, McLean, VA.
Eileen M O'ReillyMemorial Sloan Kettering Cancer Center, New York, NY.
Harvard University · USMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USCedars-Sinai Medical Center · USGeorge Mason University · USJohns Hopkins University · USPancreatic Cancer Action Network · USUniversity of California, San Francisco · USVirginia Cancer Institute · USWashington University in St. Louis · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeIn pancreatic cancer (PC), the

methodsClinical outcomes were assessed across a multi-institutional case series of 81 patients with

resultsThe frequency of RAF alterations in PC was 2.2% (84 of 3,781) within a prevalence cohort derived from large molecular databases where

conclusionProspective evaluation of

Indexed as

AgedExonsFemaleHumansMaleMAP Kinase Signaling SystemMiddle AgedMutationNeoplasm MetastasisPancreatic NeoplasmsProtein Kinase InhibitorsProto-Oncogene Proteins B-rafRetrospective StudiesSurvival AnalysisBRAF protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins B-raf

Identifiers

PMID34476331
PMCPMC8407652
OpenAlexW3194554695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.