Evidence map›Paper›PMID 34476220›Full record

ArticleFrontiers in cellular and infection microbiology2021

Repurposing Carvedilol as a Novel Inhibitor of the

Cynthia Vanesa Rivero, Santiago José Martínez, Paul Novick, Juan Agustín Cueto, Betiana Nebaí Salassa, María Cristina Vanrell, Xiaomo Li, Carlos Alberto Labriola, Luis Mariano Polo, David M Engman and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Reporter genes and transgenicFrontiers in medicine · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage inFrontiers in cellular and infection microbiology · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Cynthia Vanesa RiveroLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
Santiago José MartínezLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
Paul NovickDepartment of Chemistry, Stanford University, San Francisco, CA, United States.
Juan Agustín CuetoLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
Betiana Nebaí SalassaLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
María Cristina VanrellLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
Xiaomo LiLeishmaniasis Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Carlos Alberto LabriolaLaboratorio de Biología estructural y celular, Fundación Instituto Leloir (FIL-CONICET), Buenos Aires, Argentina.
Luis Mariano PoloInstituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
David M EngmanDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, United States.
Joachim ClosLeishmaniasis Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Patricia Silvia RomanoLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARBernhard Nocht Institute for Tropical Medicine · DEInstituto de Histología y Embriología de Mendoza · ARUniversidad Nacional de Cuyo · ARCedars-Sinai Medical Center · USFundación Instituto Leloir · ARStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ParasitesTrypanosoma cruziAnimalsAutophagyCarvedilolDrug RepositioningMiceCarvedilolautophagy flux inhibitorChagas diseasedrug repurposingmice infectiontrypanocidal drugsTrypanosoma cruzi

Identifiers

PMID34476220
PMCPMC8406938
OpenAlexW3190015463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.