ArticleQuantitative imaging in medicine and surgery2021
Cross-reactivity among iodinated contrast agents: should we be concerned?
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Shortage of iodinated contrast media: Status and possible chances - A systematic review.European journal of radiology · 2023Pooled it
- Localized Facial Bullous Eruption Following Iodinated Contrast in a Patient With Renal Failure.Cureus · 2026Article
- Characterization and diagnostic evaluation of hypersensitivity to iodinated contrast media: A retrospective analysis.The World Allergy Organization journal · 2026Article
- Pharmacovigilance analysis of iodinated contrast media related respiratory adverse effects based on the FDA adverse event reporting system.Frontiers in pharmacology · 2026Article
- Risk factor analysis of iodinated contrast medium-related hypersensitivity reactions.Insights into imaging · 2025Review
- Characterization of Hypersensitivity to Iodinated Contrast Media: Insights from a Six-Year Cohort of 26,465 Procedures.Healthcare (Basel, Switzerland) · 2025Article
- Hypersensitivity reactions to iodinated contrast media: potential mechanisms and clinical management.Frontiers in medicine · 2025Review
- Insights into nanoparticle surface bonding and coating architecture via multinuclear NMR.Academia nano : science, materials, technology · 2025Article
- Cross-reactivity in hypersensitivity reactions to contrast agents: new classification and guide for clinical practice.European radiology · 2024Article
- Prophylaxis after contrast media-induced drug reaction with eosinophilia and systemic symptoms syndrome: our personal experience.European heart journal. Case reports · 2024Article
- Which prophylaxis is senseful after contrast-induced drug rash with eosinophilia and systemic symptoms? The role of double prophylaxis and chemical cross-reactivity.European heart journal. Case reports · 2024Article
- The role of iodinated contrast media in computed tomography structured Reporting and Data Systems (RADS): a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Radiocontrast Media Hypersensitivity Reactions in Children.Medicina (Kaunas, Lithuania) · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several papers deal with "cross-reactivity" in patients with iodinated contrast medium (ICM) hypersensitivity reactions (HSRs), there is no in-depth knowledge of this phenomenon. To define ICM-groups as potential reaction partners and to identify any potential clinical relevance in patients with ICM-HSRs.
methodsThe literature database PubMed was searched for eligible papers dealing with ICM-allergy and "cross-reactivity". The data presented by the papers was analyzed and individual patient data was extracted for re-evaluation based on a definition for both 'polyvalent reactivity' and 'cross-reactivity' as well as for chemical structure-dependent ICM-groups.
resultsTwenty-five original papers (with n=340 extracted patients) formed the study population. Incidences of polyvalent reactivity were non-significantly higher than incidences of cross-reactivity (both range from 0% to 100%). Crossover evaluation in reaction pairings (culprit ICM A with ICM B versus culprit ICM B with ICM A) showed concordance of only 30%. Data support rather non-cross-reactivity (individual reaction pattern) than cross-reactivity constellations.
conclusionsThe obtained results favour an individual reaction pattern, rather than a reactivity driven by chemical structures and so-called cross-reactivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.