Evidence map›Paper›PMID 34476178›Full record

ArticleQuantitative imaging in medicine and surgery2021

Left atrial strain measured by 4D Auto LAQ echocardiography is significantly correlated with high risk of thromboembolism in patients with non-valvular atrial fibrillation.

Lili Chen, Chunquan Zhang, Jiangtao Wang, Liangyun Guo, Xiaolin Wang, Fengzhen Liu, Xia Li, Yu Zhao

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
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Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lili ChenDepartment of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanhang, China.
Chunquan ZhangDepartment of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanhang, China.
Jiangtao WangGE Clinical Education Team, Beijing, China.
Liangyun GuoDepartment of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanhang, China.
Xiaolin WangDepartment of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanhang, China.
Fengzhen LiuDepartment of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanhang, China.
Xia LiDepartment of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanhang, China.
Yu ZhaoDepartment of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanhang, China.
Nanchang University · CNSecond Affiliated Hospital of Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 4-dimensional automated left atrial quantification (4D Auto LAQ) tool is a new software for analysis of the structure and function of the left atrium (LA). This study aimed to evaluate the relationship between LA strain (LAS) as measured by 4D Auto LAQ echocardiography and thromboembolism risk in patients with non-valvular atrial fibrillation (NVAF).

methodsEight-five patients with NVAF were recruited from the cardiovascular center of our hospital, including 39 patients at high risk and 46 patients at low risk of thromboembolism. The study participants were assessed by routine echocardiography; 4D images were obtained, after which 4D Auto LAQ assessment was performed.

resultsIn the thromboembolism high-risk group, the rates of impaired LA reservoir strain, LA contraction strain, LA reservoir circumferential strain, LA conduit circumferential strain, and LA contraction circumferential strain were found to be significantly higher than in the low-risk group. However, there was no significant difference in volume at onset of LA contraction or LA ejection fraction (LAEF) between the 2 groups. LA contraction circumferential strain was found to be an independent high risk factor for thromboembolism [odds ratio (OR): 2.52; P=0.008]. LA contraction circumferential strain >-4.5% was the cut-off for differentiating between participants with high and low risk of thromboembolism, with an area under the curve (AUC) of 0.95 (P<0.0001), a sensitivity of 0.872, and a specificity of 0.978. Sequential analysis revealed that LA contraction circumferential strain had a high diagnostic efficacy for stroke, as well as a specified accuracy in the diagnosis of hypertension and diabetes in patients aged ≥65 years old. However, it was not found to be effective in the diagnosis of heart failure and vascular diseases.

conclusionsLAS is a useful index for the dynamic evaluation of LA function in patients with non-valvular AF, with higher sensitivity and accuracy than LA volume. LA contraction circumferential strain is an independent high risk factor for thromboembolism, and LA contraction circumferential strain >-4.5% is a valuable cut-off to guide the use of anticoagulant therapy in patients with non-valvular AF.

Indexed as

4-Dimensional Automated Left Atrial Quantification (4D Auto LAQ)CHA2DS2-VASC scoreleft atrial strain (LAS)Non-valvular atrial fibrillation (NVAF)

Identifiers

PMID34476178
PMCPMC8339650
OpenAlexW3168265266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.