ReviewPlastic and reconstructive surgery. Global open2021
Outcomes of Lymphovenous Anastomosis for Upper Extremity Lymphedema: A Systematic Review.
Review in Plastic and reconstructive surgery. Global open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05441943 (Lymphaticovenous Anastomosis as a Surgical Treatment for Breast Cancer-Related Lymphedema), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lymphaticovenous Anastomosis as a Surgical Treatment for Breast Cancer-Related Lymphedema
Who cites it
13 citing papers in PubMed.
- Economic evaluation of lymphaticovenous anastomosis versus conservative therapy for breast cancer-related lymphoedema: secondary outcome analysis of a randomized clinical trial.The British journal of surgery · 2026Trial
- Review
- Pilot Study: Postoperative Evaluation of Upper Extremity Lymphedema Using a Cutometer: A Single-center Prospective Observational Study.Plastic and reconstructive surgery. Global open · 2026Article
- A Prospective Study of the Impact of Lymphatic Venous Anastomosis as a Treatment for Lymphedema.Plastic and reconstructive surgery. Global open · 2025Article
- Development of an All-Wales National Health Service Surgical Lymphedema Supermicrosurgery Service.Plastic and reconstructive surgery. Global open · 2025Article
- Advances in surgical management of chronic lymphedema: current strategies and future directions.Medical oncology (Northwood, London, England) · 2025Review
- [Cost comparison of conservative vs. surgical treatment of chronic lymphedema].Chirurgie (Heidelberg, Germany) · 2025Article
- Evolving Role of Lymphedema Surgery on Breast Reconstruction: A Systematic Review and Multi-Institutional Algorithmic Approach.Journal of clinical medicine · 2024Review
- MRI-CEUS fusion-guided lymphatic mapping as a preoperative strategy for lymphedema patients undergoing lymphaticovenous anastomosis surgery.Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- Supermicrosurgical lymphovenous anastomosis.Journal of the Chinese Medical Association : JCMA · 2024Review
- Prophylactic Lymphovenous Bypass at the Time of Axillary Lymph Node Dissection Decreases Rates of Lymphedema.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023Article
- What do we know about treating breast-cancer-related lymphedema? Review of the current knowledge about therapeutic options.Breast cancer (Tokyo, Japan) · 2023Review
- Distally Prophylactic Lymphaticovenular Anastomoses after Axillary or Inguinal Complete Lymph Node Dissection Followed by Radiotherapy: A Case Series.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLymphovenous anastomosis (LVA) is an accepted microsurgical treatment for lymphedema of the upper extremity (UE). This study summarizes and analyzes recent data on the outcomes associated with LVA for UE lymphedema at varying degrees of severity.
methodsA literature search was conducted in the PubMed database to extract articles published through June 19, 2020. Studies reporting data on postoperative improvement in limb circumference/volume or subjective improvement in quality of life for patients with primary or secondary lymphedema of the UE were included. Extracted data consisted of demographic data, number of patients and upper limbs, duration of symptoms before LVA, surgical technique, follow-up, and objective and subjective outcomes.
resultsA total of 92 articles were identified, of which 16 studies were eligible for final inclusion comprising a total of 349 patients and 244 upper limbs. The average age of patients ranged from 38.4 to 64 years. The duration of lymphedema before LVA ranged from 9 months to 7 years. The mean length of follow-up ranged from 6 months to 8 years. Fourteen studies reported an objective improvement in limb circumference or volume measurements following LVA, ranging from 0% to 100%. Patients included had varying severity of lymphedema, ranging from Campisi stage I to IV. The maximal improvement in objective measurements was found in patients with lower stage lymphedema.
conclusionLVA is a safe, effective technique for the treatment of UE lymphedema refractory to decompressive treatment. Results of LVA indicate greater efficacy in earlier stages of lymphedema before advanced lymphatic sclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.