ArticleNeurology. Clinical practice2021
How Multiple Sclerosis Symptoms Vary by Age, Sex, and Race/Ethnicity.
Article in Neurology. Clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 71 citations in OpenAlex.
- Randomized Controlled Trial of the Behavioral Intervention for Physical Activity in Multiple Sclerosis Project: Response Heterogeneity and Predictors of Change.International journal of behavioral medicine · 2025Trial
- The Effect of the Team Members Teaching Design vs. Regular Lectures method on the Self-efficacy of the Multiple sclerosis Patients in Iran. Randomised Controlled Trial.Investigacion y educacion en enfermeria · 2024Trial
- Phenotyping healthcare use before pediatric-onset multiple sclerosis, including by sex and age: A matched cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Article
- Differences in Income Growth Between People With Multiple Sclerosis and Controls: A Norwegian Cohort Study.European journal of neurology · 2026Article
- Disparities in imaging and management of multiple sclerosis: a review.The British journal of radiology · 2026Review
- Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.Neuropsychology · 2026Article
- Article
- Review
- Sleep-Disordered Breathing Shortly After Stroke Is Not Associated With Poststroke Fatigue at 3 Months.Neurology open access · 2025Article
- Rationale for a 4-month, parallel-group, randomized controlled trial to assess the Feasibility and Efficacy of a Remotely delivered exercise training intervention for Hispanics/Latinos with Multiple Sclerosis (FERLA MS).Pilot and feasibility studies · 2025Article
- A Qualitative Inquiry of Exercise Preferences among Hispanic Adults with Multiple Sclerosis.American journal of lifestyle medicine · 2025Article
- Differential Fatigue Profile in Patients with Post-COVID Condition, Fibromyalgia, and Multiple Sclerosis.Journal of clinical medicine · 2025Article
- CONFIDENCE treatment success: long-term real-world effectiveness and safety of ocrelizumab in Germany.Frontiers in neurology · 2025Article
- Major depressive disorder in multiple sclerosis associated with differences in disease modifying therapy and demographics.Frontiers in neurology · 2025Article
- Testing Polynomial (Non-Linear) Effects of Neurological and Physical Disability on Sexual Well-Being in Multiple Sclerosis.Brain sciences · 2024Article
- The intersection of race and sex on the clinical and cognitive progression of multiple sclerosis.Journal of the neurological sciences · 2024Article
- Lutein improves remyelination by reducing of neuroinflammation in C57BL/6 mouse models of multiple sclerosis.Heliyon · 2024Article
- The Role of Sex and Other Personal Characteristics in the Effects of Symptoms Severity on Self-Care Agency in Individuals with Multiple Sclerosis.Brain and behavior · 2024Article
- Bioinformatics approaches for studying molecular sex differences in complex diseases.Briefings in bioinformatics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLittle is known about how symptom severity in the various neurologic domains commonly affected by multiple sclerosis (MS) varies by age, sex, and race/ethnicity.
methodsThis was a retrospective study of patients with MS attending 2 tertiary centers in the New York City metropolitan area, who self-identified as White, African American (AA), or Hispanic American (HA). Disability was rated with Patient-Determined Disability Steps (PDDS) and symptom severity, with SymptoMScreen (SyMS), a validated battery for assessing symptoms in 12 domains. Analyses comparing race, sex, and age groups were performed using analysis of variance models and Tukey honestly significant difference tests to control the overall type I error. A multivariable model was constructed to predict good self-rated health (SRH) that included demographic variables, PDDS, and SyMS domain scores.
resultsThe sample consisted of 2,622 patients with MS (age 46.4 years; 73.6% female; 66.4% White, 21.7% AA, and 11.9% HA). Men had higher adjusted PDDS than women (
conclusionsAA and HA race/ethnicity was associated with higher overall disability, higher symptom severity in each of the 12 domains commonly affected by MS, and worse SRH relative to Whites. However, only symptom severity and disability, and not demographic variables, predicted good SRH.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.