ArticleACS macro letters2021
Sequence Blockiness Controls the Structure of Polyampholyte Necklaces.
Article in ACS macro letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A Sequence-Specific Theory for Charge-Regulating IDPs.The journal of physical chemistry. B · 2026Article
- Mapping Charge Interactions in Intrinsically Disordered Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Manifold of Polyampholyte Necklaces: From Charge Migration to Hierarchical Structure.Macromolecules · 2025Article
- The Origin of the Ionic-strength Dependent Reentrant Behavior in Liquid-Liquid Phase Separation of Uncharged IDPs.bioRxiv : the preprint server for biology · 2025Article
- Article
- Beyond monopole electrostatics in regulating conformations of intrinsically disordered proteins.PNAS nexus · 2024Article
- Sequence-Dependent Conformational Transitions of Disordered Proteins During Condensation.bioRxiv : the preprint server for biology · 2024Article
- The juxtamembrane linker of synaptotagmin 1 regulates CaNature communications · 2024Article
- The juxtamembrane linker of synaptotagmin 1 regulates CabioRxiv : the preprint server for biology · 2023Article
- Review
- Effect of Charge Distribution on the Dynamics of Polyampholytic Disordered Proteins.Macromolecules · 2022Article
- Diffusion of dyes in polyelectrolyte-surfactant hydrogels.RSC advances · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A scaling theory of statistical (Markov) polyampholytes is developed to understand how sequence correlations, that is, the blockiness of positive and negative charges, influences conformational behavior. An increase in the charge patchiness leads to stronger correlation attractions between oppositely charged monomers, but simultaneously, it creates a higher charge imbalance in the polyampholyte. A competition between effective short-range attractions and long-range Coulomb repulsions induces globular, pearl-necklace, or fully stretched chain conformations, depending on the average length of the block of like charges. The necklace structure and the underlying distribution of the net charge are also controlled by the sequence. Sufficiently long blocks allow for charge migration from globular beads (pearls) to strings, thereby providing a nonmonotonic change in the number of necklace beads as the blockiness increases. The sequence-dependent structure of polyampholyte necklaces is confirmed by molecular dynamics simulations. The findings presented here provide a framework for understanding the sequence-encoded conformations of synthetic polyampholytes and intrinsically disordered proteins (IDPs).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.