Evidence map›Paper›PMID 34476090›Full record

ArticleClinical kidney journal2021

Renoprotective role of bariatric surgery in patients with established chronic kidney disease.

Enrique Morales, Esteban Porrini, Marina Martin-Taboada, Sergio Luis-Lima, Rocío Vila-Bedmar, Ignacio González de Pablos, Pilar Gómez, Elías Rodríguez, Lucia Torres, Borja Lanzón and 4 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Cardiorenal outcomes of weight loss interventions in people with CKD and type 2 diabetes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  5. Article
  6. Measurement, Estimation, and Correlates of the GFR before and after Bariatric Surgery.Journal of the American Society of Nephrology : JASN · 2026
    Article
  7. Review
  8. Obesity-Related Kidney Disease: A Growing Threat to Renal Health.International journal of molecular sciences · 2025
    Review
  9. Review
  10. Review
  11. Chronic kidney disease combined with metabolic syndrome is a non-negligible risk factor.Therapeutic advances in endocrinology and metabolism · 2024
    Review
  12. Article
  13. The Fat Kidney.Current obesity reports · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Glomerular hyperfiltration.Nature reviews. Nephrology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Enrique MoralesDepartment of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID https://orcid.org/0000-0002-5824-6973
Esteban PorriniFaculty of Medicine, Instituto de Tecnologías Biomédicas, University of La Laguna, Laguna, Spain.
Marina Martin-TaboadaDepatment Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Madrid, Spain.
Sergio Luis-LimaDepartment of Nephrology and Hypertension, IIS-Fundación Jimenez Díaz, Madrid, Spain.
Rocío Vila-BedmarDepatment Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Madrid, Spain.
Ignacio González de PablosDepartment of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Pilar GómezDepartment of Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain.
Elías RodríguezDepartment of Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain.
Lucia TorresDepatment Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Madrid, Spain.
Borja LanzónDepatment Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Madrid, Spain.
Ana Elena RodríguezFundación General de la ULL, Instituto de Tecnologias Biomédicas, Madrid, Spain.
María MaízDepartment of Endocrinology, Hospital Universitario, 12 de Octubre, Madrid, Spain.
Gema Medina-GómezDepatment Basic Sciences of Health, Faculty of Sciences of Health, Universidad Rey Juan Carlos, Madrid, Spain.
Manuel PragaDepartment of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Universidad Rey Juan Carlos · ESHospital Universitario 12 De Octubre · ESResearch Institute Hospital 12 de Octubre · ESFundación General · ESHospital Universitario Fundación Jiménez Díaz · ESUniversidad de La Laguna · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBariatric surgery (BS) has been postulated as the most effective measure for weight reduction. Weight loss improves metabolic parameters and exerts changes in renal function that lead to the amelioration of absolute or relative glomerular hyperfiltration, a condition that may be renoprotective in the long term. However, few studies have demonstrated the influence of BS in patients with severe obesity and chronic kidney disease (CKD). Our objective was to analyse the evolution of renal function, adipose tissue-derived molecules and inflammatory parameters in patients with CKD after BS.

methodsThis is an observational and prospective study. Thirty patients were screened and 12 were included between January 2016 and January 2018 with a 24-month follow-up. Glomerular filtration rate (GFR) was determined by plasma iohexol clearance. Adipokines, cytokines, circulating hormones and fibrotic parameters were evaluated before and 12 months after BS using the Bioplex system.

resultsThe mean age was 50.6 years and 58.3% were males. Seven patients had a body mass index >40 kg/m

conclusionsBS is an effective option to prevent kidney damage in obese subjects with CKD due to the improvement of glomerular hyperfiltration, adipocyte cytokines metabolic and inflammatory parameters.

Indexed as

adipocytokinesbariatric surgerychronic kidney diseasehyperfiltrationobesitypro-inflammatory cytokinesproteinuriatriglycerides

Identifiers

PMID34476090
PMCPMC8406062
OpenAlexW3116699239

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.