Evidence map›Paper›PMID 34476069›Full record

ArticleChemical science2021

Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin.

Xuqiao Hu, Hongyan Li, Tiffany Ka-Yan Ip, Yam Fung Cheung, Mohamad Koohi-Moghadam, Haibo Wang, Xinming Yang, Daniel N Tritton, Yuchuan Wang, Yi Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. The arsenic proteome in cancer: Unravelling molecular mechanisms of anticancer drugs.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Memory effects of prior subculture may impact the quality of multiomic perturbation profiles.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Molecular Chaperonin HSP60: Current Understanding and Future Prospects.International journal of molecular sciences · 2024
    Review
  14. Review
  15. Article
  16. Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton.Chembiochem : a European journal of chemical biology · 2023
    Review
  17. Article
  18. Article
  19. Mechanistic update of Trisenox in blood cancer.Current research in pharmacology and drug discovery · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xuqiao HuDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Hongyan LiDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Tiffany Ka-Yan IpDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Yam Fung CheungDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Mohamad Koohi-MoghadamDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Haibo WangDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Xinming YangDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Daniel N TrittonDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Yuchuan WangDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Yi WangDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.ORCID https://orcid.org/0000-0003-0797-5209
Runming WangDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.
Kwan-Ming NgDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.ORCID https://orcid.org/0000-0003-4353-9658
Hua NaranmanduraDepartment of Toxicology, School of Medicine and Public Health, Zhejiang University Hangzhou P.R. China.ORCID https://orcid.org/0000-0003-0799-2340
Eric Wai-Choi TseDepartment of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong P. R. China.ORCID https://orcid.org/0000-0002-8351-4722
Hongzhe SunDepartment of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong Hong Kong SAR P. R. China hsun@hku.hk.ORCID https://orcid.org/0000-0001-6697-6899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms of action of arsenic trioxide (ATO), a clinically used drug for the treatment of acute promyelocytic leukemia (APL), have been actively studied mainly through characterization of individual putative protein targets. There appear to be no studies at a system level. Herein, we integrate metalloproteomics through a newly developed organoarsenic probe, As-AC (C

Identifiers

PMID34476069
PMCPMC8372542

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.