ReviewChemical science2021
Expanding organofluorine chemical space: the design of chiral fluorinated isosteres enabled by I(i)/I(iii) catalysis.
Review in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Direct Regioselective para-Fluorination via I(I)/I(III) Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Difluorinative Cyclopropene Rearrangement by I(I)/I(III) Catalysis: Regio- and Stereoselective Synthesis of Allyl Difluorides.Angewandte Chemie (International ed. in English) · 2025Article
- Acidity Controlled Formal Nucleophilic Substitution of Hydrofluoroolefin-Based Iodonium Salt with O-nucleophiles: Synthetic Application and Mechanistic Study.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Privileged Chiral Photocatalysts.Angewandte Chemie (International ed. in English) · 2025Review
- Regioselective fluorination of allenes enabled by I(I)/I(III) catalysis.Nature communications · 2024Article
- Conformational Analysis of 1,3-Difluorinated Alkanes.The Journal of organic chemistry · 2024Article
- Article
- Article
- Enyne difluorination.Nature chemistry · 2023Article
- Regioselective, catalytic 1,1-difluorination of enynes.Nature chemistry · 2023Article
- Integrating I(I)/I(III) catalysis in reaction cascade design enables the synthesis of gem-difluorinated tetralins from cyclobutanols.Nature communications · 2023Article
- Catalytic, Regioselective 1,4-Fluorodifunctionalization of Dienes.Angewandte Chemie (International ed. in English) · 2023Article
- Skeletal Ring Contractions via I(I)/I(III) Catalysis: Stereoselective Synthesis ofACS catalysis · 2022Article
- Catalytic Stereoconvergent Synthesis of Homochiral β-CFACS organic & inorganic Au · 2022Article
- Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction.Chemical science · 2022Article
- Regio- and Enantioselective Intermolecular Aminofluorination of Alkenes via Iodine(I)/Iodine(III) Catalysis.Angewandte Chemie (International ed. in English) · 2022Article
- Carbodefluorination of fluoroalkyl ketones via a carbene-initiated rearrangement strategy.Nature communications · 2022Article
- Stereocontrolled Synthesis of Fluorinated Isochromans via Iodine(I)/Iodine(III) Catalysis.Angewandte Chemie (International ed. in English) · 2022Article
- Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters.Chemical science · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short aliphatic groups are prevalent in bioactive small molecules and play an essential role in regulating physicochemistry and molecular recognition phenomena. Delineating their biological origins and significance have resulted in landmark developments in synthetic organic chemistry: Arigoni's venerable synthesis of the chiral methyl group is a personal favourite. Whilst radioisotopes allow the steric footprint of the native group to be preserved, this strategy was never intended for therapeutic chemotype development. In contrast, leveraging H → F bioisosterism provides scope to complement the chiral, radioactive bioisostere portfolio and to reach unexplored areas of chiral chemical space for small molecule drug discovery. Accelerated by advances in I(i)/I(iii) catalysis, the current arsenal of achiral 2D and 3D drug discovery modules is rapidly expanding to include chiral units with unprecedented topologies and van der Waals volumes. This
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.