Evidence map›Paper›PMID 34475951›Full record

ArticleInternational journal of endocrinology2021

Detection of Circulating Tumor DNA in Patients with Thyroid Nodules.

Krupal B Patel, Nicholas Cormier, James Fowler, Allison Partridge, Julie Theurer, Morgan Black, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Detection of theJournal of clinical medicine · 2024
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Krupal B PatelDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-2285-0386
Nicholas CormierDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
James FowlerDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Allison PartridgeDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Julie TheurerDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Morgan BlackDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Nicole PintoDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
John YooDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Kevin FungDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Danielle MacNeilDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
William StechoDepartment of Pathology, Western University, London, Ontario, Canada.
Christopher HowlettDepartment of Pathology, Western University, London, Ontario, Canada.
Muriel BrackstoneDepartment of Surgery, Western University, London, Ontario, Canada.
John W BarrettDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0003-3708-3834
Anthony NicholsDepartment of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-0760-980X
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDetection of circulating tumor DNA (ctDNA) in cancer patients can potentially serve as a noninvasive, sensitive test of disease status. The purpose of this study was to determine the ability to detect

methodsConsecutive patients with thyroid nodules who consented for surgery were recruited. Plasma samples were obtained preoperatively and one month postoperatively. Quantitative PCR was used to determine the levels of the

resultsA total of 109 patients were recruited. On final pathology, 38 (32.8%) patients had benign thyroid nodules, 45 (38.8%) had classical papillary thyroid cancer (PTC), 23 (19.8%) had nonclassical PTC, and 3 (2.6%) had follicular thyroid cancer. 15/109 patients had detectable

conclusion

Identifiers

PMID34475951
PMCPMC8407979
OpenAlexW3193850327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.