ArticlePakistan journal of medical sciences
Predictive factors of treatment success in two-dose methotrexate regimen in ectopic tubal pregnancy: A retrospective study.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- Evaluation of the relationships between beta-human chorionic gonadotropin (β-hCG) blood levels and pregnancy: A retrospective study.Pakistan journal of medical sciences · 2025Article
- Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- Predictive value of serum βHCG level in ectopic pregnancy: A cross sectional study.Health science reports · 2023Article
- Treatment success with two doses of methotrexate vs single dose of methotrexate in Ectopic Tubal Pregnancy.Pakistan journal of medical sciencesArticle
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Authors and funding
2 authors.
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Abstract
objectivesTo investigate the predictive factors of success or failure in treating ectopic tubal pregnancies with two-dose methotrexate (MTX).
methodsThe records of patients treated for tubal EP with two-dose MTX were retrospectively reviewed. Patients were divided into two groups; the Group-I (failure) consisted of patients who did not respond to MTX therapy and the Group-II (success) included patients who were successfully treated with MTX. Parameters, including the week of gestation, presence or absence of fetal cardiac activity, gestational sac size, serum β-hCG levels, and adverse effects were compared.
resultsFifty patients were included in this study, 8 (16%) were in Group-I and 42 (84%) were in Group-II. Patients in Group-I required surgery after a mean duration of 6.7±3 days after administering the initial dose of MTX. There was no difference between the groups in terms of the week of gestation, presence or absence of fetal cardiac activity, gestational sac size, serum β-hCG levels, and adverse effects. The average time to β-hCG negativization was 31 days in Group-II.
conclusionsThe two-dose MTX protocol has a reasonable success rate, which seems to be dependent on serum β-hCG levels.
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