Evidence map›Paper›PMID 34475868›Full record

Trial reportFrontiers in immunology2021

Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection.

Katrine Schou Sandgaard, Ben Margetts, Teresa Attenborough, Triantafylia Gkouleli, Stuart Adams, Mette Holm, Diana Gibb, Deena Gibbons, Carlo Giaquinto, Anita De Rossi and 5 more

Open access · goldAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Evolution of CD4 T-Cell Count With Age in a Cohort of Young People Growing Up With Perinatally Acquired Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Katrine Schou SandgaardGreat Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Ben MargettsMolecular Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
Teresa AttenboroughGreat Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Triantafylia GkouleliGreat Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Stuart AdamsMolecular Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
Mette HolmDepartment of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
Diana GibbMedical Research Council Clinical Trials Unit, London, United Kingdom.
Deena GibbonsPeter Gorer Department of Immunobiology, Kings College London, London, United Kingdom.
Carlo GiaquintoDepartment of Mother and Child Health, University of Padova, Padova, Italy.
Anita De RossiSection of Oncology and Immunology, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Alasdair BamfordGreat Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Paolo PalmaClinical and Research Unit of Clinical Immunology and Vaccinology, Academic Department of Pediatrics, Children Hospital Bambino Gesù - IRCCS, Rome, Italy.
Benny ChainDivision of Infection and Immunity, University College London, London, United Kingdom.
Athina S GkaziZayed Centre for Research into Rare Disease in Children, University College London, London, United Kingdom.
Nigel KleinGreat Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Great Ormond Street Hospital · GBUniversity College London · GBIstituti di Ricovero e Cura a Carattere Scientifico · ITAarhus University Hospital · DKKing's College London · GBMedical Research Council · GBUniversity of Padua · IT

Funding

Medical Research Council MC_UU_00004/03
6 · The paper itself

Abstract

It is intriguing that, unlike adults with HIV-1, children with HIV-1 reach a greater CD4

Indexed as

Antiretroviral Therapy, Highly ActiveAdolescentAnti-HIV AgentsCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChildChild, PreschoolFollow-Up StudiesHIV-1HIV InfectionsHumansImmune SystemReceptors, Antigen, T-CellViral LoadAnti-HIV AgentsReceptors, Antigen, T-Cellantiretroviral treatment interruptionhigh throughout sequencingHIV-1immune repertoiresT cell receptorT cell receptor clonal expansionsT cellsthymic output

Identifiers

PMID34475868
PMCPMC8406805
OpenAlexW3190615431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.