Evidence map›Paper›PMID 34475865›Full record

ArticleFrontiers in microbiology2021

Synbiotics Containing Nanoprebiotics: A Novel Therapeutic Strategy to Restore Gut Dysbiosis.

Liang Hong, Sang-Mok Lee, Whee-Soo Kim, Yun-Jaie Choi, Seo-Ho Oh, Yu-Ling Li, Seung-Hoon Choi, Dong Hyen Chung, Eunkyoung Jung, Sang-Kee Kang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Synbiotic Administration of d-Tagatose andFood science & nutrition · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liang HongTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Sang-Mok LeeDepartment of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
Whee-Soo KimDepartment of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
Yun-Jaie ChoiDepartment of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
Seo-Ho OhDepartment of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
Yu-Ling LiDepartment of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
Seung-Hoon ChoiInsilico Co., Ltd., Ansan-Si, South Korea.
Dong Hyen ChungInsilico Co., Ltd., Ansan-Si, South Korea.
Eunkyoung JungInsilico Co., Ltd., Ansan-Si, South Korea.
Sang-Kee KangInstitutes of Green-Bio Science & Technology, Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang, South Korea.
Chong-Su ChoDepartment of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new formulation, nanoprebiotics [e.g., phthalyl pullulan nanoparticles (PPNs)], was demonstrated to enhance the antimicrobial activity of probiotics [e.g.,

Indexed as

cross-feedingdysbiosisendotoxingut barrier reinforcementgut microbiotananoprebioticspathogenic infectionsynbiotics

Identifiers

PMID34475865
PMCPMC8406803

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.