ReviewFrontiers in human neuroscience2021
The SEEKING Drive and Its Fixation: A Neuro-Psycho-Evolutionary Approach to the Pathology of Addiction.
Review in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Prometheus unbound? Oceanic affectivity and the neuropsychodynamics of addiction.Frontiers in psychology · 2026Article
- Review
- Fear of negative evaluation mediates and core self-evaluation moderates the relationship between social comparison orientation and social network addiction.Scientific reports · 2025Article
- Placing problematic media use in context: a research synthesis, person-centric framework, and chart review among a clinical sample of US youth.Frontiers in psychiatry · 2025Article
- Study to Evaluate the Comparative Efficacy of Medhya Rasayana (Pharmacological) Versus Nonpharmacological Interventions in Management of Gadget Addiction in Children: Protocol for Parallel, Triple-Arm, Randomized Clinical Trial.JMIR research protocols · 2024Article
- The interplay between social media use and problematic internet usage: Four behavioral patterns.Heliyon · 2023Article
- Behavioral domains in compulsive rats: implications for understanding compulsive spectrum disorders.Frontiers in behavioral neuroscience · 2023Article
- Article
- Relationship between behavioral inhibition/activation system and Internet addiction among Chinese college students: The mediating effects of intolerance of uncertainty and self-control and gender differences.Frontiers in public health · 2022Article
- Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration.Frontiers in human neuroscience · 2022Article
- Flights and Perchings of the BrainMind: A Temporospatial Approach to Psychotherapy.Frontiers in psychology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuro-ethological studies conducted by Panksepp and his colleagues have provided an understanding of how the activity of the mesolimbic dopaminergic (ML DA) system leads to the emotional disposition to SEEK/Explore, which is involved in all appetitive motivated behavior and mental activity. In pathological addiction phenomena, this emotional disposition "fixes" itself on certain obsessive-compulsive habits, losing its versatility and its natural predisposition to spontaneous and unconditioned activation. Overall, the result is a consistent disinterest in everything that is not the object of addiction. From a neuro-psycho-evolutionary point of view, the predisposition to develop addictive behavior can be attributed to a loss of "functional autonomy" of the SEEKING/Explorative disposition. Indeed, as shown by animal and human studies, the tendency to be conditioned by situations and contexts that provide an immediate reward can be closely related to a deficit in the tonic endogenous activity of the ML DA-SEEKING system.
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