Evidence map›Paper›PMID 34475812›Full record

ArticleFrontiers in neuroscience2021

Visual Impairments Are Associated With Retinal Microvascular Density in Patients With Parkinson's Disease.

Min Zhou, Lei Wu, Qinyuan Hu, Congyao Wang, Jiacheng Ye, Tingting Chen, Pengxia Wan

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Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Retinal microvascular alterations in Parkinson's disease: visual analysis and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Min ZhouDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Lei WuDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Qinyuan HuDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Congyao WangDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jiacheng YeDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Tingting ChenDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Pengxia WanDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to evaluate retinal microvascular density in patients with Parkinson's disease (PD) and its correlation with visual impairment.

methodsThis cross-sectional study included 24 eyes of 24 patients with PD and 23 eyes of 23 healthy controls. All participants underwent ophthalmic examination, visual evoked potential (VEP) test, 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), and optical coherence tomography angiography (OCTA) examination. The correlation between retinal microvascular density and visual parameter was evaluated using Spearman correlation analysis, and the area under receiver operating characteristic curve (AUROC) was calculated.

resultsParkinson's disease patients had prolonged P100 latency (

conclusionThis study demonstrated that decreased retinal microvascular density was correlated with visual impairment in PD patients. Retinal microvasculature change may occur earlier than visual decline and retinal structure change and has the potential to be a promising diagnostic marker for early PD.

Indexed as

optical coherence tomography angiographyParkinson’s diseaseretinal microvascular densityvisual evoked potentialvisual impairment

Identifiers

PMID34475812
PMCPMC8406760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.