Evidence map›Paper›PMID 34475744›Full record

ArticleAnnals of gastroenterology

Outcomes among inpatients with cirrhosis and

Sentia Iriana, Sachit Sharma, Stephanie McDonough, Eduardo Rodriguez Zarate, Douglas G Adler

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Clinical analysis ofWorld journal of hepatology · 2024
    Article
  2. Canadian journal of gastroenterology & hepatology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sentia IrianaDepartment of Gastroenterology and Hepatology, University of Utah, Salt Lake City UT (Sentia Iriana, Stephanie McDounough, Eduardo Rodriguez Zarate, Douglas G. Adler).
Sachit SharmaDepartment of Internal Medicine, University of Toledo, Toledo OH (Sachit Sharma), USA.
Stephanie McDonoughDepartment of Gastroenterology and Hepatology, University of Utah, Salt Lake City UT (Sentia Iriana, Stephanie McDounough, Eduardo Rodriguez Zarate, Douglas G. Adler).
Eduardo Rodriguez ZarateDepartment of Gastroenterology and Hepatology, University of Utah, Salt Lake City UT (Sentia Iriana, Stephanie McDounough, Eduardo Rodriguez Zarate, Douglas G. Adler).
Douglas G AdlerDepartment of Gastroenterology and Hepatology, University of Utah, Salt Lake City UT (Sentia Iriana, Stephanie McDounough, Eduardo Rodriguez Zarate, Douglas G. Adler).
University of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with cirrhosis are at increased risk of

methodsThe Nationwide Inpatient Sample from 2016-2017 identified 8245 hospitalized patients with a concurrent diagnosis of cirrhosis and CDI. Our primary outcome was in-hospital all-cause mortality. Secondary outcomes were length of stay (LOS), hospitalization charges and costs, shock, sepsis, acute kidney injury (AKI), intensive care unit (ICU) admission, and home discharge.

resultsThere was no significant difference in all-cause in-hospital mortality between patients with cirrhosis compared to patients without cirrhosis (adjusted odds ratio [aOR] 1.31, 95% confidence interval [CI] 0.89-1.93; P=0.16). Patients with cirrhosis had a slightly but statistically significantly longer mean LOS (+0.57 days, P=0.001). The adjusted difference in mean hospitalization charges was greater in patients with cirrhosis ($+4094, 95%CI $1080-7108; P=0.008), as was the mean hospitalization cost ($+1349, 95%CI $600-2098; P<0.001). There was no difference in the likelihood of sepsis, ICU admission, or home discharge between the groups. Patients with cirrhosis were significantly less likely to develop AKI (aOR 0.82, 95%CI 0.72-0.93; P=0.003).

conclusionsMortality outcomes associated with CDI have improved over time. Patients with cirrhosis continue to exhibit greater LOS and hospital costs.

Indexed as

acute kidney injuryCirrhosisClostridioides difficile infectionNational Inpatient Sample

Identifiers

PMID34475744
PMCPMC8375645
OpenAlexW3167744702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.