Evidence map›Paper›PMID 34475743›Full record

ArticleAnnals of gastroenterology

Epidemiology of neuroendocrine tumors of the appendix in the USA: a population-based national study (2014-2019).

Motasem Alkhayyat, Mohannad Abou Saleh, Wendy Coronado, Mohammad Abureesh, Mohammad Zmaili, Thabet Qapaja, Ashraf Almomani, George Khoudari, Emad Mansoor, Gregory Cooper

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Neuroendocrine tumors of the appendix: a comprehensive review of the literature and case presentation.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Motasem AlkhayyatInternal Medicine Department, Cleveland Clinic Foundation, Cleveland, Ohio (Motasem Alkhayyat, Wendy Coronado, Mohammad Zmaili, Thabet Qapaja, Ashraf Almomani).
Mohannad Abou SalehGastroenterology, Hepatology, and Nutrition, Cleveland Clinic Foundation, Cleveland, Ohio (Mohannad Abou Saleh).
Wendy CoronadoInternal Medicine Department, Cleveland Clinic Foundation, Cleveland, Ohio (Motasem Alkhayyat, Wendy Coronado, Mohammad Zmaili, Thabet Qapaja, Ashraf Almomani).
Mohammad AbureeshInternal Medicine Department, Staten Island University Hospital, Staten Island, NY (Mohammad Abureesh).
Mohammad ZmailiInternal Medicine Department, Cleveland Clinic Foundation, Cleveland, Ohio (Motasem Alkhayyat, Wendy Coronado, Mohammad Zmaili, Thabet Qapaja, Ashraf Almomani).
Thabet QapajaInternal Medicine Department, Cleveland Clinic Foundation, Cleveland, Ohio (Motasem Alkhayyat, Wendy Coronado, Mohammad Zmaili, Thabet Qapaja, Ashraf Almomani).
Ashraf AlmomaniInternal Medicine Department, Cleveland Clinic Foundation, Cleveland, Ohio (Motasem Alkhayyat, Wendy Coronado, Mohammad Zmaili, Thabet Qapaja, Ashraf Almomani).
George KhoudariDepartment of Hospital Medicine, Cleveland Clinic Foundation, Cleveland, Ohio (George Khoudari).
Emad MansoorGastroenterology and Hepatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio (Emad Mansoor, Gregory Cooper), USA.
Gregory CooperGastroenterology and Hepatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio (Emad Mansoor, Gregory Cooper), USA.
Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe appendix is the third most common place for neuroendocrine tumors (NETs) along the digestive tract and NETs are the most common neoplasms of the appendix. However, there are limited population-based data on the epidemiology of this disease. Using a large database, we sought to describe the epidemiology and risk association of NETs of the appendix.

methodWe queried a multi-institutional database (Explorys Inc., Cleveland, OH, USA), comprising 360 hospitals in the United States (US), for patients with a diagnosis of NETs of the appendix from 2014-2019.

resultsOf the 30,324,050 individuals in the database, 2020 patients had an appendiceal NET diagnosis (0.007%). The most common presenting symptoms included abdominal pain, nausea, vomiting and diarrhea. Patients with appendiceal NETs were more likely to be female (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.24-1.49), Caucasian (OR 2.71, 95%CI 2.40-3.07), with a history of smoking (OR 1.82, 95%CI 1.65-2.01), family history of primary gastrointestinal malignancy (OR 7.26, 95%CI 6.31-8.33), diagnosis of multiple endocrine tumor type 1 (OR 52.31, 95%CI 23.15-118.23), or neurofibromatosis type 1 (OR 16.37, 95%CI 7.24-37.01).

conclusionsIn a population-based study in the US, using the Explorys database, we found the overall prevalence of NETs of the appendix to be 7 per 100,000 persons. The incidence in the year January 2019-January 2020 was 0.4 per 100,000 individuals. These rates are higher than previously reported and may be more accurate, given the more comprehensive nature of the Explorys database.

Indexed as

appendixepidemiologyNeuroendocrine tumorrisk factors

Identifiers

PMID34475743
PMCPMC8375642
OpenAlexW3172408358

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.