Evidence map›Paper›PMID 34475640›Full record

ArticleJournal of parasitic diseases : official organ of the Indian Society for Parasitology2021

Assessment of chitosan nanoparticles in improving the efficacy of nitazoxanide on cryptosporidiosis in immunosuppressed and immunocompetent murine models.

Howayda Said Fouad Moawad, Mohamed Hegab Abd El-Hady Hegab, Maha Saber Reda Badawey, Shaimaa Elsayed Ashoush, Shereen Mahmoud Ibrahim, Amira Abd El-Lateef Saleh Ali

Open access · greenAbstract read
In one paragraph

Article in Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Molecular and serological assessment of the therapeutic efficacy of Ivermectin Loaded nanoparticles onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Article
  3. Efficacy of nitazoxanide, ivermectin and albendazole in treatment of cryptosporidiosis in immunosuppressed mice.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Article
  4. Article
  5. Therapeutic potential of platelet rich plasma against experimentalJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
    Article
  6. Use of nanoparticles, a modern means of drug delivery, against cryptosporidiosis.Journal of advanced veterinary and animal research · 2023
    Review
  7. Article
  8. Article
  9. Apoptotic changes in the intestinal epithelium ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Howayda Said Fouad MoawadFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Mohamed Hegab Abd El-Hady HegabFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Maha Saber Reda BadaweyFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Shaimaa Elsayed AshoushFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Shereen Mahmoud IbrahimFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Amira Abd El-Lateef Saleh AliFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptosporidiosis is one of the major causes of diarrhea in immunocompetent and immunocompromised patients. It is self-limited in immunocompetent individuals. However, in the immunocompromised it can cause life-threatening diarrhea and results in chronic malabsorption of fluids, vitamins and electrolytes resulting in wasting. Our study is concerned with assessing and comparing the efficacy of nitazoxanide (NTZ) alone and NTZ loaded chitosan nanoparticles (NTZ loaded CS NPs) in the treatment of experimental cryptosporidiosis using parasitological and histopathological parameters. One hundred mice were divided into 5 groups (20 mice each). Each group was divided into 2 subgroups according to the immune status [a-immunocompetent, b-immunosuppressed]. group 1: control (healthy), group 2: control infected by

Indexed as

Chitosan nanoparticlesCryptosporidiumImmunocompetent and immunosuppressionNitazoxanide

Identifiers

PMID34475640
PMCPMC8368908
OpenAlexW3118852871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.