Evidence map›Paper›PMID 34475610›Full record

ArticleOrganometallics2021

A Strategy to Conjugate Bioactive Fragments to Cytotoxic Diiron Bis(cyclopentadienyl) Complexes.

Silvia Schoch, Mouna Hadiji, Sarah A P Pereira, M Lúcia M F S Saraiva, Simona Braccini, Federica Chiellini, Tarita Biver, Stefano Zacchini, Guido Pampaloni, Paul J Dyson and 1 more

Abstract read
In one paragraph

Article in Organometallics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Silvia SchochUniversity of Pisa, Dipartimento di Chimica e Chimica Industriale, 56124 Pisa, Italy.
Mouna HadijiInstitut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Sarah A P PereiraLAQV, REQUIMTE, Laboratório de Química Aplicada, Faculdade de Farmácia, da Universidade do Porto, Porto, Portugal.
M Lúcia M F S SaraivaLAQV, REQUIMTE, Laboratório de Química Aplicada, Faculdade de Farmácia, da Universidade do Porto, Porto, Portugal.ORCID https://orcid.org/0000-0001-6539-1741
Simona BracciniUniversity of Pisa, Dipartimento di Chimica e Chimica Industriale, 56124 Pisa, Italy.
Federica ChielliniUniversity of Pisa, Dipartimento di Chimica e Chimica Industriale, 56124 Pisa, Italy.ORCID https://orcid.org/0000-0003-4680-9975
Tarita BiverUniversity of Pisa, Dipartimento di Farmacia, 56126 Pisa, Italy.ORCID https://orcid.org/0000-0001-8512-8422
Stefano ZacchiniUniversity of Bologna, Dipartimento di Chimica Industriale "Toso Montanari", 40136 Bologna, Italy.ORCID https://orcid.org/0000-0003-0739-0518
Guido PampaloniUniversity of Pisa, Dipartimento di Chimica e Chimica Industriale, 56124 Pisa, Italy.ORCID https://orcid.org/0000-0002-6375-4411
Paul J DysonInstitut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-3117-3249
Fabio MarchettiUniversity of Pisa, Dipartimento di Chimica e Chimica Industriale, 56124 Pisa, Italy.ORCID https://orcid.org/0000-0002-3683-8708

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of bioactive molecules were synthesized from the condensation of aspirin or chlorambucil with terminal alkynes bearing alcohol or amine substituents. Insertion of the resulting alkynes into the iron-carbyne bond of readily accessible diiron bis(cyclopentadienyl) μ-aminocarbyne complexes, [

Identifiers

PMID34475610
PMCPMC8397425

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.