ArticleNature nanotechnology2021
Unveiling the full reaction path of the Suzuki-Miyaura cross-coupling in a single-molecule junction.
Article in Nature nanotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Precise Probing of Interfaces at the Single-Molecule Scale.Nanomaterials (Basel, Switzerland) · 2026Review
- Origin of Single-Molecule Reaction Chirality.Research (Washington, D.C.) · 2026Article
- Graphene-based molecular junctions achieve nanosecond-level reaction dynamic analysis and efficient on-chip synthesis.National science review · 2025Article
- Nanosecond-scale single-molecule reaction dynamics for scalable synthesis on a chip.National science review · 2025Article
- Direct observation and force modulation of single-bond reactions at the ion/metal interface.Science advances · 2025Article
- Emergent complexity of quantum rotation tunneling.Science advances · 2025Article
- Full on-device manipulation of olefin metathesis for precise manufacturing.Nature nanotechnology · 2025Article
- Unveiling the Mechanism of Deprotonation and Proton Transfer of DNA Polymerase Catalysis via Single-Molecule Conductance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Electrical monitoring of single-event protonation dynamics at the solid-liquid interface and its regulation by external mechanical forces.Nature communications · 2024Article
- Massive acceleration of SChemical science · 2024Article
- Technologies for investigating single-molecule chemical reactions.National science review · 2024Review
- Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Regulation of quantum spin conversions in a single molecular radical.Nature nanotechnology · 2024Article
- Phase transfer catalysts shift the pathway to transmetalation in biphasic Suzuki-Miyaura cross-couplings.Nature communications · 2024Article
- Nuclear Magnetic Resonance Chemical Shift as a Probe for Single-Molecule Charge Transport.Angewandte Chemie (International ed. in English) · 2024Article
- Review
- Total variation denoising-based method of identifying the states of single molecules in break junction data.Discover nano · 2024Article
- The role of halogens in Au-S bond cleavage for energy-differentiated catalysis at the single-bond limit.Nature communications · 2023Article
- Real-time monitoring of reaction stereochemistry through single-molecule observations of chirality-induced spin selectivity.Nature chemistry · 2023Article
- Research on Electric Field-Induced Catalysis Using Single-Molecule Electrical Measurement.Molecules (Basel, Switzerland) · 2023Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional analytic techniques that measure ensemble averages and static disorder provide essential knowledge of the reaction mechanisms of organic and organometallic reactions. However, single-molecule junctions enable the in situ, label-free and non-destructive sensing of molecular reaction processes at the single-event level with an excellent temporal resolution. Here we deciphered the mechanism of Pd-catalysed Suzuki-Miyaura coupling by means of a high-resolution single-molecule platform. Through molecular engineering, we covalently integrated a single molecule Pd catalyst into nanogapped graphene point electrodes. We detected sequential electrical signals that originated from oxidative addition/ligand exchange, pretransmetallation, transmetallation and reductive elimination in a periodic pattern. Our analysis shows that the transmetallation is the rate-determining step of the catalytic cycle and clarifies the controversial transmetallation mechanism. Furthermore, we determined the kinetic and thermodynamic constants of each elementary step and the overall catalytic timescale of this Suzuki-Miyaura coupling. Our work establishes the single-molecule platform as a detection technology for catalytic organochemistry that can monitor transition-metal-catalysed reactions in real time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.