Evidence map›Paper›PMID 34475455›Full record

ArticleScientific reports2021

The shared genetic architecture between epidemiological and behavioral traits with lung cancer.

Rowland W Pettit, Jinyoung Byun, Younghun Han, Quinn T Ostrom, Jacob Edelson, Kyle M Walsh, Melissa L Bondy, Rayjean J Hung, James D McKay, Christopher I Amos

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  4. The Current Roadmap of Lung Cancer Biology, Genomics and Racial Disparity.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Rowland W PettitInstitute for Clinical and Translational Research, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Jinyoung ByunInstitute for Clinical and Translational Research, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Younghun HanInstitute for Clinical and Translational Research, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Quinn T OstromDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.
Jacob EdelsonDepartment of Biomedical Data Science, School of Medicine, Stanford University, Stanford, CA, USA.
Kyle M WalshDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.
Melissa L BondyDepartment of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, USA.
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.
James D McKaySection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Christopher I AmosInstitute for Clinical and Translational Research, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. Chris.Amos@bcm.edu.
Baylor College of Medicine · USDuke Medical Center · USStanford University · USCentre International de Recherche sur le Cancer · FRLunenfeld-Tanenbaum Research Institute · CA

Funding

Translating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Mattias Alexander Johansson · 2017 to 2026
$23.7M
International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
Infrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9M
Training in Precision Environmental Health SciencesT32ES027801 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2018 to 2026
$2.8M
NCI NIH HHS R01 CA139020NCI NIH HHS U01 CA167462NCI NIH HHS U19 CA203654NIEHS NIH HHS T32 ES027801NIH HHS T32ES027801NIH HHS U19CA203654World Health Organization 001
6 · The paper itself

Abstract

The complex polygenic nature of lung cancer is not fully characterized. Our study seeks to identify novel phenotypes associated with lung cancer using cross-trait linkage disequilibrium score regression (LDSR). We measured pairwise genetic correlation (r

Indexed as

Multifactorial InheritanceAge FactorsAlcohol DrinkingBody Mass IndexCase-Control StudiesDatabases, GeneticEducationGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInternational AgenciesLinkage DisequilibriumLung NeoplasmsPhenotypePolymorphism, Single NucleotideUnited Kingdom

Identifiers

PMID34475455
PMCPMC8413319
OpenAlexW3196711288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.