Evidence map›Paper›PMID 34475242›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Systemic Radiopharmaceutical Therapy of Pheochromocytoma and Paraganglioma.

Jorge A Carrasquillo, Clara C Chen, Abhishek Jha, Karel Pacak, Daniel A Pryma, Frank I Lin

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Endocrine oncology (Bristol, England) · 2025
    Article
  7. Article
  8. Diagnostic performance of [European radiology · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Case Series:Frontiers in endocrinology · 2024
    Article
  14. Article
  15. The Efficacy of PretreatmentClinical Medicine Insights. Oncology · 2023
    Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Jorge A CarrasquilloMolecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York; carrasj1@mskcc.org.
Clara C ChenDepartment of Radiology, Clinical Center, National Institutes of Health, Bethesda, Maryland.
Abhishek JhaSection on Medical Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; and.
Karel PacakSection on Medical Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; and.
Daniel A PrymaDepartment of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania.
Frank I LinMolecular Imaging Branch, National Cancer Institute, Bethesda, Maryland.
Health and Human Development (2HD) Research Network · CMHospital of the University of Pennsylvania · USMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · USNational Institutes of Health Clinical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Intramural NIH HHS ZIA HD008735NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Whereas benign pheochromocytomas and paragangliomas are often successfully cured by surgical resection, treatment of metastatic disease can be challenging in terms of both disease control and symptom control. Fortunately, several options are available, including chemotherapy, radiation therapy, and surgical debulking. Radiolabeled metaiodobenzylguanidine (MIBG) and somatostatin receptor imaging have laid the groundwork for use of these radiopharmaceuticals as theranostic agents.

Indexed as

Adrenal Gland NeoplasmsParagangliomaPheochromocytomaRadiopharmaceuticals3-IodobenzylguanidineHumans3-IodobenzylguanidineRadiopharmaceuticalsDOTATATEMIBGparagangliomapeptide receptor radionuclide therapypheochromocytomasomatostatin

Identifiers

PMID34475242
PMCPMC8882896
OpenAlexW3196582845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.