Evidence map›Paper›PMID 34475208›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling.

Jason F Cooper, Ryan J Guasp, Meghan Lee Arnold, Barth D Grant, Monica Driscoll

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Nonapoptotic role of EGL-1 in exopher production and neuronal health inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Journal of biosciences · 2025
    Review
  15. Article
  16. Extracellular vesicles.Genetics · 2024
    Review
  17. Article
  18. Non-apoptotic role of EGL-1 in exopher production and neuronal health inbioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jason F CooperDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854.ORCID 0000-0002-5725-5288
Ryan J GuaspDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854.ORCID 0000-0001-9832-6735
Meghan Lee ArnoldDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854.
Barth D GrantDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854.
Monica DriscollDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854; driscoll@biology.rutgers.edu.ORCID 0000-0002-8751-7429

Funding

CENTER FOR CAENORHABDITIS ELGANS ANATOMYR24RR012596 · NCRR · YESHIVA UNIVERSITY · PI HALL, DAVID H. · 1998 to 2011
$8.0M
Defining Roles of Genetics and Age in Extrusion of Neurotoxic AggregatesR37AG056510 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI MONICA A. DRISCOLL · 2017 to 2026
$5.3M
Understanding the Exopher: A Novel Mechanism for Extrusion of Neurotoxic ContentsR01AG047101 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI DRISCOLL, MONICA A., GRANT, BARTH DEMIAN · 2013 to 2022
$4.2M
NCRR NIH HHS R24 RR012596NIA NIH HHS R01 AG047101NIA NIH HHS R37 AG056510
6 · The paper itself

Abstract

In human neurodegenerative diseases, neurons can transfer toxic protein aggregates to surrounding cells, promoting pathology via poorly understood mechanisms. In

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEpidermal Growth FactorFibroblast Growth FactorsGenes, rasLipogenesisMAP Kinase Signaling SystemNeurodegenerative DiseasesNeuronsOxidation-ReductionSignal TransductionStress, PhysiologicalCaenorhabditis elegans ProteinsEpidermal Growth FactorFibroblast Growth FactorsexopherfastingMAP kinaseneurologystress

Identifiers

PMID34475208
PMCPMC8433523

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.