Evidence map›Paper›PMID 34475207›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme.

Dayna C Patterson, Myrrh Perez Ruiz, Hyerin Yoon, Johnnie A Walker, Jean-Paul Armache, Neela H Yennawar, Emily E Weinert

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dayna C PattersonDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0003-1950-0331
Myrrh Perez RuizDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0003-3620-8738
Hyerin YoonDepartment of Chemistry, Emory University, Atlanta, GA 30322.
Johnnie A WalkerDepartment of Chemistry, Emory University, Atlanta, GA 30322.
Jean-Paul ArmacheDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0001-9195-2282
Neela H YennawarThe Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0001-7278-659X
Emily E WeinertDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802; emily.weinert@psu.edu.ORCID 0000-0002-4986-8682
Pennsylvania State University · USEmory University · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
NIGMS NIH HHS P30 GM124166
6 · The paper itself

Abstract

Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a second messenger that modulates bacterial cellular processes, including biofilm formation. While proteins containing both c-di-GMP synthesizing (GGDEF) and c-di-GMP hydrolyzing (EAL) domains are widely predicted in bacterial genomes, it is poorly understood how domains with opposing enzymatic activity are regulated within a single polypeptide. Herein, we report the characterization of a globin-coupled sensor protein (GCS) from

Indexed as

Amino Acid SequenceBacterial ProteinsBiofilmsCyclic GMPEscherichia coli ProteinsGene ExpressionGene Expression Regulation, BacterialLigandsPaenibacillusPhosphoric Diester HydrolasesPhosphorus-Oxygen LyasesProtein DomainsSecond Messenger SystemsBacterial ProteinsCyclic GMPdiguanylate cyclaseEscherichia coli ProteinsLigandsPhosphoric Diester HydrolasesPhosphorus-Oxygen Lyasesbifunctional enzymecyclic di-GMPheme sensor

Identifiers

PMID34475207
PMCPMC8433548
OpenAlexW3196945052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.