ArticleAJNR. American journal of neuroradiology2021
DWI in Brains of Fetuses with Congenital Heart Disease: A Case-Control MR Imaging Study.
Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- MRI evaluation of ADC values and venous variations in fetal cerebral white matter with T2WI signal hyperintensity in late gestation.Frontiers in medicine · 2026Article
- Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- Sex differences in normal fetal regional brain apparent diffusion coefficient changes assessed byFrontiers in pediatrics · 2024Article
- Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease.Frontiers in cardiovascular medicine · 2024Review
- Fetal MRI at 3 T: Principles to Optimize Success.Radiographics : a review publication of the Radiological Society of North America, Inc · 2023Article
- Altered white matter connectivity in children with congenital heart disease with single ventricle physiology.Scientific reports · 2023Article
- Regional changes in brain apparent diffusion coefficient in fetuses with complex congenital heart disease and normal pregnancy assessed using diffusion-weighted imaging.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAbnormal ADC values are seen in ischemic brain lesions such as acute or chronic hypoxia. We aimed to assess whether ADC values in the developing brain measured by in utero DWI were different in fetuses with congenital heart disease compared with healthy controls. MATERIALS AND
methodsIn utero DWI was performed in 50 fetuses with congenital heart disease and 100 healthy controls at a similar gestational age. Pair-wise ADC values of the ROIs were manually delineated on each side of the frontal and periatrial WM and in the basal ganglia, thalamus, and cerebellar hemisphere, as well as a single measurement in the pons.
resultsFetuses with congenital heart disease had significantly lower ADC values in frontal and periatrial WM and the pons than controls (all
conclusionsAbnormal brain diffusivity can be detected using in utero DWI in fetuses with congenital heart disease. Abnormal ADC values found at a mean gestational age of 26 weeks suggest structural changes, which may provide an early indicator of the impact of congenital heart disease on the developing brain.
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