ArticleAJNR. American journal of neuroradiology2021
Dual-Energy Parathyroid 4D-CT: Improved Discrimination of Parathyroid Lesions from Thyroid Tissue Using Noncontrast 40-keV Virtual Monoenergetic Images.
Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- Preoperative prediction of perineural invasion in pancreatic ductal adenocarcinoma using dual-layer spectral CT.Abdominal radiology (New York) · 2026Article
- Deep learning image reconstruction for 50-keV virtual monoenergetic dual-energy CT of the thyroid: a prospective "dual-low" dose study.European radiology · 2026Article
- Limited additional value of dual-layer spectral 4DCT compared with conventional 4DCT for preoperative localization in primary hyperparathyroidism.European journal of radiology open · 2025Article
- Dual-energy CT combined with histogram parameters in the assessment of perineural invasion in colorectal cancer.International journal of colorectal disease · 2025Article
- Image quality improvement in head and neck angiography based on dual-energy CT and deep learning.BMC medical imaging · 2025Article
- Four-Dimensional Dual-Energy Computed Tomography-Derived Parameters and Their Correlation with Thyroid Gland Functional Status.Tomography (Ann Arbor, Mich.) · 2025Article
- Refining the role of presurgical PET/4D-CT in a large series of patients with primary hyperparathyroidism undergoing [European journal of clinical investigation · 2025Article
- Imaging Recommendations for Diagnosis and Management of Primary Parathyroid Pathologies: A Comprehensive Review.Cancers · 2024Review
- Quantitative parameters of dual-layer spectral detector computed tomography for evaluating Ki-67 and human epidermal growth factor receptor 2 expression in colorectal adenocarcinoma.Quantitative imaging in medicine and surgery · 2024Article
- Can spectral computed tomography (CT) replace perfusion CT to assess the histological classification of non-small cell lung cancer?Quantitative imaging in medicine and surgery · 2023Article
- Utility of non-contrast Dual Energy Computed Tomography in diagnosis of differentiated thyroid cancer - two case study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment.Head & neck · 2023Article
- The effect of computed tomography parameters on sarcopenia and myosteatosis assessment: a scoping review.Journal of cachexia, sarcopenia and muscle · 2022Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeIn parathyroid CT, a noncontrast phase aids discrimination of parathyroid lesions (not iodine-containing) from thyroid tissue (iodine-containing). When thyroid iodine is pathologically diminished, this differentiation is difficult with standard CT. Because the attenuation of an element is maximal near its K-edge (iodine = 33.2 keV), we hypothesized that dual-energy CT 40-keV virtual monoenergetic images will accentuate thyroid iodine relative to standard images, improving the differentiation of thyroid from parathyroid lesions. Our purpose was to test this hypothesis through quantitative assessment of Hounsfield unit attenuation and contrast-to-noise on dual-energy CT standard (70-keV) and 40-keV noncontrast images. MATERIALS AND
methodsFor this retrospective study including 20 dual-energy parathyroid CTs, we used an ROI-based analysis to assess the attenuation of thyroid tissue, parathyroid lesions, and sternocleidomastoid muscle as well as corresponding contrast-to-noise on standard and 40- keV noncontrast images. Wilcoxon signed rank tests were performed to compare differences between 70 and 40 keV.
resultsAbsolute and percentage increases in attenuation at 40 keV were significantly greater for thyroid gland than for parathyroid lesions and sternocleidomastoid muscle (
conclusionsForty-kiloelectron volt virtual monoenergetic images facilitate discrimination of parathyroid lesions from thyroid tissue by significantly increasing thyroid attenuation and associated contrast-to-noise. These findings are particularly relevant for parathyroid lesions that exhibit isoattenuation to the thyroid on parathyroid CT arterial and venous phases and could, therefore, be missed without the noncontrast phase.
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