ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021
A Clinical PET Imaging Tracer ([
Open access · bronzeAbstract read
In one paragraph
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
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- Hydrogen peroxide and cisplatin regulate the ROS/PKM2 pathway to affect the growth of cancer.American journal of cancer research · 2025Article
- Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T.Magnetic resonance in medicine · 2024Article
- M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance.Neuro-oncology · 2023Article
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Corrections and comments
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Authors and funding
36 authors at 4 institutions in 3 countries.
Corinne Beinat *Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California. cbeinat@stanford.edu lrecht@stanford.edu.ORCID 0000-0003-1718-3272
Chirag B Patel *Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Tom HaywoodDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Surya MurtyDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Lewis NayaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.ORCID 0000-0003-4701-2554
Jessa B CastilloDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Samantha T ReyesDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.ORCID 0000-0002-2584-5902
Megan PhillipsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.
Pablo BuccinoDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Bin ShenDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Jun Hyung ParkDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Mary Ellen I KoranDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, California.ORCID 0000-0002-3322-9114
Israt S AlamDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Michelle L JamesDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Dawn HolleyDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Kim HalbertDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Harsh GandhiDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.
Joy Q HeStanford Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California.
Monica GranucciDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Eli JohnsonDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Daniel Dan LiuStanford Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California.ORCID 0000-0003-0100-5973
Nobuko UchidaStanford Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California.
Rahul SinhaStanford Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California.
Pauline ChuStanford Human Research Histology Core, Stanford University School of Medicine, Stanford, California.
Donald E BornDepartment of Pathology, Neuropathology, Stanford University School of Medicine, Stanford, California.ORCID 0000-0001-6102-512X
Geoffrey I WarnockPMOD Technologies Ltd, Zurich, Switzerland.
Irving WeissmanStanford Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California.
Melanie Hayden-GephartDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Mehdi KhalighiDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.ORCID 0000-0001-5623-1922
Tarik F MassoudDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.ORCID 0000-0002-9694-1408
Andrei IagaruDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, California.ORCID 0000-0003-0839-5329
Guido DavidzonDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, California.ORCID 0000-0001-5579-6825
Reena ThomasDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.
Seema NagpalDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.ORCID 0000-0002-0289-2319
Lawrence D RechtDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California. cbeinat@stanford.edu lrecht@stanford.edu.
Sanjiv Sam GambhirDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California.ORCID 0000-0002-2711-7554
Stanford Medicine · USStanford University · USCalifornia Institute for Regenerative Medicine · USUniversity of Zurich · CH
Funding
Stanford Neurosurgery Resident Research Education ProgramR25NS065741 · NINDS · STANFORD UNIVERSITY · PI HAYDEN GEPHART, MELANIE, STEINBERG, GARY K · 2009 to 2022
$2.0M(PQ1) Identifying and targeting human glioblastoma migrating in the peritumoral nicheR01CA216054 · NCI · STANFORD UNIVERSITY · PI HAYDEN GEPHART, MELANIE · 2017 to 2021
$1.7MDEFINING THE MEDULLOBLASTOMA CANCER STEM CELL LINEAGE HIERARCHY BY NOTCH SIGNALINGF30CA228215 · NCI · STANFORD UNIVERSITY · PI HE, JOY · 2018 to 2021
$132kNCI NIH HHS F30 CA228215NCI NIH HHS R01 CA216054NINDS NIH HHS R25 NS065741
Abstract
purposePyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) cells with minimal expression in healthy brain. We describe the development, validation, and translation of a novel PET tracer to study PKM2 in GBM. We evaluated 1-((2-fluoro-6-[ EXPERIMENTAL
design[
resultsIn mouse imaging studies, [
conclusionsWe developed and translated [
Indexed as
Brain NeoplasmsGlioblastomaAnimalsDiazonium CompoundsGlycolysisHumansMicePositron-Emission TomographyPyruvate KinaseSulfanilic Acidsdiazobenzenesulfonic acidDiazonium CompoundsPyruvate KinaseSulfanilic Acids
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.