ArticleMaterials science & engineering. C, Materials for biological applications2021
Hydrothermally treated titanium surfaces for enhanced osteogenic differentiation of adipose derived stem cells.
Article in Materials science & engineering. C, Materials for biological applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Hierarchical Peptide Functionalized Titania Nanotubes: Improving Stability, Promoting Osteogenesis, and Reducing Infection Risk.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Construction and Properties of SPI/PLA-PCL Composite Coating on Pure Titanium Surface.Micromachines · 2026Article
- Nano-engineering the titanium-tissue interface: a 15 year perspective on bio-functionalization and surface innovation.Nanoscale advances · 2026Review
- Mastoid Obliteration After Canal Wall Down Mastoidectomy Using Tissue Engineering Approaches with Polymers, Mesenchymal Stem Cells, and Bioactive Molecules: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Advances in Dealloying of Ti and Ti-Based Alloys for Biomedical Applications.Materials (Basel, Switzerland) · 2025Review
- ZnO and ZnS Hybrid Film Enhances the Bone Regeneration Performance of Zinc-Based Implants.ACS omega · 2025Article
- Comparative Analysis of Local Application of Titanium-Platelet Rich Fibrin (T-PRF) and Leukocyte-Platelet Rich Fibrin (L-PRF) in Bone Defect Healing: A Micro-CT and Histopathological Study in Rabbit Models.Microscopy research and technique · 2025Article
- Bioactive Glass and Melittin Thin Films Deposited by MAPLE for Titanium Implant Functionalization.Materials (Basel, Switzerland) · 2025Article
- Sustained release of Sr and Ca from a micronanotopographic titanium surface improves osteoblast function.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Anti-Bacterial Properties and Hemocompatibility of Alkali Treated Nano-Structured Micro-Porous Titanium Surfaces.Biomimetics (Basel, Switzerland) · 2025Article
- Significant Interaction between Melatonin and Titanium Bone Implants: Available Evidence and Future Research Directions.Current pharmaceutical biotechnology · 2025Review
- A multifunctional composite scaffold responds to microenvironment and guides osteogenesis for the repair of infected bone defects.Journal of nanobiotechnology · 2024Article
- Synthesis of Heterostructured TiOMaterials (Basel, Switzerland) · 2024Article
- Engineering a Hybrid Ti6Al4V-Based System for Responsive and Consistent Osteogenesis.ACS omega · 2024Article
- Novel Strategy for Surface Modification of Titanium Implants towards the Improvement of Osseointegration Property and Antibiotic Local Delivery.Materials (Basel, Switzerland) · 2023Article
- Biomaterials combined with ADSCs for bone tissue engineering: current advances and applications.Regenerative biomaterials · 2023Review
- Improved Hemocompatibility on Superhemophobic Micro-Nano-Structured Titanium Surfaces.Bioengineering (Basel, Switzerland) · 2022Article
- Surface-modified WE43 magnesium alloys for reduced degradation and superior biocompatibility.In vitro models · 2022Article
- Improved in vitro endothelialization on nanostructured titania with tannin/glycosaminoglycan-based polyelectrolyte multilayers.In vitro models · 2022Article
- The Importance of Correlation between CBCT Analysis of Bone Density and Primary Stability When Choosing the Design of Dental Implants-Ex Vivo Study.Tomography (Ann Arbor, Mich.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Implant surface plays a crucial role in improving osseointegration and long-term implant life. When the implant comes in contact with the bone tissue, the bone marrow mesenchymal cells interact with the implant surface and the surface properties such as morphology, wettability, mechanical properties and chemistry influences cell migration, proliferation and differentiation. Different surface modification strategies such as ceramic coatings, surface dealloying, and surface topography modifications for improving osteointegration have been investigated. However, studies have not yet established which of the surface property is more influential. In this study, titanium surfaces were treated hydrothermally with sodium hydroxide and sulfuric acid separately. This treatment led to the development of two unique surface topography at nanoscale. These modified surfaces were characterized for surface morphology, wettability, chemistry, and crystallinity. Cytotoxicity, cell adhesion, proliferation, morphology, and differentiation of adipose derived stem cells on modified surfaces was investigated. The results indicate that wettability does influence initial cell adhesion. However, the surface morphology can play major role in cell spreading, proliferation and differentiation. The results indicate that titanium surfaces treated hydrothermally with sodium hydroxide led to a nanoporous architecture that promoted appropriate cell interaction with the surface promoting osteoblastic lineage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.