Slowly expanding lesions are a marker of progressive MS - Yes.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

8 citing papers in PubMed.

1. The hypoxia-inflammation cycle as a key mechanism of smoldering inflammation and progression in multiple sclerosis.Acta neuropathologica · 2026
   Review
2. Progressive multiple sclerosis: Evaluating current therapies and exploring future treatment strategies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
   Review
3. Current challenges in secondary progressive multiple sclerosis: diagnosis, activity detection and treatment.Frontiers in immunology · 2025
   Review
4. Paramagnetic rim lesions are associated with inner retinal layer thinning and progression independent of relapse activity in multiple sclerosis.European journal of neurology · 2025
   Article
5. Paramagnetic rim lesions lead to pronounced diffuse periplaque white matter damage in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023
   Article
6. Bruton tyrosine kinase inhibitors for multiple sclerosis.Nature reviews. Neurology · 2023
   Review
7. Predictive MRI Biomarkers in MS-A Critical Review.Medicina (Kaunas, Lithuania) · 2022
   Review
8. Peripheral Hemolysis in Relation to Iron Rim Presence and Brain Volume in Multiple Sclerosis.Frontiers in neurology · 2022
   Article

Corrections and comments

• Commented on by
  Slowly expanding lesions are a marker of progressive MS - Commentary.2021

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as