ArticleLab on a chip2021
Monitoring the effects of chemical stimuli on live cells with metasurface-enhanced infrared reflection spectroscopy.
Article in Lab on a chip, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Dynamically tunable membrane metasurfaces for infrared spectroscopy and strong light-matter interactions.Light, science & applications · 2026Article
- Polarization-independent dielectric gradient near-perfect absorbers for aqueous mid-infrared molecular sensing.Npj nanophotonics · 2026Article
- Combining quantum cascade lasers and plasmonic metasurfaces to monitorNanophotonics (Berlin, Germany) · 2025Article
- Review
- Metasurface-enhanced biomedical spectroscopy.Nanophotonics (Berlin, Germany) · 2025Review
- Programmable optical meta-holograms.Nanophotonics (Berlin, Germany) · 2024Review
- Dielectric metasurfaces for next-generation optical biosensing: a comparison with plasmonic sensing.Nanotechnology · 2023Review
- Metasurface-Enhanced Mid-Infrared Spectrochemical Imaging of Tissues.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Metasurface-enhanced infrared spectroscopy in multiwell format for real-time assaying of live cells.Lab on a chip · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Infrared spectroscopy has found wide applications in the analysis of biological materials. A more recent development is the use of engineered nanostructures - plasmonic metasurfaces - as substrates for metasurface-enhanced infrared reflection spectroscopy (MEIRS). Here, we demonstrate that strong field enhancement from plasmonic metasurfaces enables the use of MEIRS as a highly informative analytic technique for real-time monitoring of cells. By exposing live cells cultured on a plasmonic metasurface to chemical compounds, we show that MEIRS can be used as a label-free phenotypic assay for detecting multiple cellular responses to external stimuli: changes in cell morphology, adhesion, and lipid composition of the cellular membrane, as well as intracellular signaling. Using a focal plane array detection system, we show that MEIRS also enables spectro-chemical imaging at the single-cell level. The described metasurface-based all-optical sensor opens the way to a scalable, high-throughput spectroscopic assay for live cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.