ReviewJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society2022
Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery.
Review in Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease.bioRxiv : the preprint server for biology · 2026Article
- [Guangdong consensus on integrated Chinese and Western medicine management of prolonged disorders of consciousness].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Alzheimer's disease and memantine effects on NMDA-receptor blockade: non-invasive in vivo insights from magnetoencephalography.Molecular psychiatry · 2026Article
- Reflections on Consciousness in Intensive Care.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Can digital brain twins dissolve the uncertainties surrounding unresponsive wakefulness?BMC medical ethics · 2026Article
- Prognostic value of auditory evoked potentials in disorders of consciousness: a systematic literature review.Clinical neurophysiology practice · 2026Review
- Development of an exploratory mismatch negativity-based prognostic nomogram for consciousness recovery in patients with prolonged disorders of consciousness: a derivation study.BMC neurology · 2025Article
- Prognostic value of brainstem auditory evoked potentials (BAEPs) and middle latency auditory evoked potentials (MLAEPs) in unconscious patients after cardiac arrest.Critical care (London, England) · 2025Article
- [Brain-computer interface technology and its applications for patients with disorders of consciousness].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- Serum glial fibrillary acidic protein and protein gene product 9.5 for predicting neurological outcomes in cardiac arrest patients with cortical response to somatosensory evoked potentials.Resuscitation plus · 2025Article
- Prognostic value of quantitative and visual electroencephalography in disorders of consciousness: a retrospective study.Frontiers in neuroscience · 2025Article
- Review
- Spectral peak analysis and intrinsic neural timescales as markers for the state of consciousness.NeuroImage. Clinical · 2024Article
- Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation.PLoS computational biology · 2023Article
- Electrophysiological and neuropsychological assessment of cognition in spinocerebellar ataxia type 1 patients: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Clinical application of recommendations for neurobehavioral assessment in disorders of consciousness: an interdisciplinary approach.Frontiers in human neuroscience · 2023Review
- Prognostication after cardiac arrest: how EEG and evoked potentials may improve the challenge.Annals of intensive care · 2022Review
- The Integration of Assistive Technology and Virtual Reality for Assessment and Recovery of Post-coma Patients With Disorders of Consciousness: A New Hypothesis.Frontiers in psychology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryThe definition of consciousness has been the subject of great interest for many scientists and philosophers. To better understand how evoked potentials may be identified as biomarkers of consciousness and recovery, the different theoretical models sustaining neural correlates of consciousness are reviewed. A multimodal approach can help to better predict clinical outcome in patients presenting with disorders of consciousness. Evoked potentials are inexpensive and easy-to-implement bedside examination techniques. Evoked potentials are an integral part of prognostic evaluation, particularly in cases of cognitive motor dissociation. Prognostic criteria are well established in postanoxic disorders of consciousness, especially postcardiac arrest but are less well determined in other etiologies. In the early examination, bilateral absence of N20 in disorder of consciousness patients is strongly associated with unfavorable outcome (i.e., death or unresponsive wakefulness syndrome) especially in postanoxic etiologies. This predictive value is lower in other etiologies and probably also in children. Both N20 and mismatch negativity are proven outcome predictors for acute coma. Many studies have shown that mismatch negativity and P3a are characterized by a high prognostic value for awakening, but some patients presenting unresponsive wakefulness syndrome also process a P3a. The presence of long-latency event-related potential components in response to stimuli is indicative of a better recovery. All neurophysiological data must be integrated within a multimodal approach combining repeated clinical evaluation, neuroimaging, functional imaging, biology, and neurophysiology combining passive and active paradigms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.