Evidence map›Paper›PMID 34474084›Full record

ArticleJournal of lipid research2021

Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A

Daiki Hayashi, Varnavas D Mouchlis, Edward A Dennis

Open access · goldAbstract read
In one paragraph

Article in Journal of lipid research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 65 citations in OpenAlex.

  1. Phospholipases: Where Do We Stand?Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Development of potent, selective cPLAnpj drug discovery · 2026
    Article
  7. The IRE1Cell stress · 2026
    Article
  8. Lipid and Metabolite Annotation Using Lipid Data Analyzer.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  9. Review
  10. Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes.Metabolomics : Official journal of the Metabolomic Society · 2025
    Review
  11. Article
  12. Specificity mechanism of Group VIA calcium-independent phospholipase ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Open life sciences · 2025
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Daiki HayashiDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Varnavas D MouchlisDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Edward A DennisDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: edennis@ucsd.edu.
University of California San Diego · US

Funding

ACTION OF LIPOLYTIC ENZYMESR01GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 1985 to 2020
$7.3M
Action of Lipolytic EnzymesR35GM139641 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EDWARD A DENNIS · 2021 to 2026
$2.6M
NIGMS NIH HHS R01 GM020501NIGMS NIH HHS R35 GM139641
6 · The paper itself

Abstract

Human phospholipase A

Indexed as

Fatty Acids, Omega-3Fatty Acids, Omega-6HumansHydrophobic and Hydrophilic InteractionsPhospholipases A2Fatty Acids, Omega-3Fatty Acids, Omega-6Phospholipases A2AAarachidonic acidDHAEPAfatty acidglycerophospholipidomega-3omega-6phospholipase A2substrate specificity

Identifiers

PMID34474084
PMCPMC8551542
OpenAlexW3197559361

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.