ArticleOphthalmology2022
Blood Pressure and Glaucomatous Progression in a Large Clinical Population.
Article in Ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The Relevance of Arterial Blood Pressure in the Management of Glaucoma Progression: A Systematic Review.American journal of hypertension · 2024Pooled it
- Morphometric Analysis of Retinal Vessels Using High-Resolution OCT Technology in Healthy Subjects.Investigative ophthalmology & visual science · 2026Observational
- Beyond intraocular pressure: vascular and metabolic modifiers of optic nerve vulnerability in glaucoma.International ophthalmology · 2026Review
- Dose-response association between metabolic abnormality burden and intraocular pressure in a population undergoing routine health examinations: a cross-sectional study.BMC ophthalmology · 2026Article
- Systemic comorbidities, seasonal onset, and antihypertensive medication use in primary angle-closure disease subtypes.International journal of ophthalmology · 2026Article
- Predictors of Glaucoma Conversion in an African Ancestry Cohort: A Longitudinal Study.American journal of ophthalmology · 2025Article
- High-Resolution Microperimetry for Detecting Glaucomatous Damage: A Prospective Evaluation of Performance.Clinical & experimental ophthalmology · 2025Article
- The arterial stiffness and pulse pressure are predictors of intraocular pressure in a middle-aged population.Scientific reports · 2025Article
- Accelerated Epigenetic Aging Is Associated with Faster Glaucoma Progression: A DNA Methylation Study.Ophthalmology · 2025Article
- Predictive modeling of rapid glaucoma progression based on systemic data from electronic medical records.Scientific reports · 2025Article
- Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition.Translational vision science & technology · 2025Article
- Effects of Telmisartan on Intraocular Pressure, Blood Pressure, and Ocular Perfusion Pressure in Normal and Glaucomatous Cats.Translational vision science & technology · 2024Article
- Advancing Glaucoma Care: Integrating Artificial Intelligence in Diagnosis, Management, and Progression Detection.Bioengineering (Basel, Switzerland) · 2024Review
- Effect of antihypertensive medications on the risk of open-angle glaucoma.Scientific reports · 2023Article
- Discrepancy between peripapillary retinal and choroidal microvasculature and the rate of localized retinal nerve fiber layer thinning in glaucoma.Scientific reports · 2023Observational
- Associations of Midlife and Late-Life Blood Pressure Status With Late-Life Retinal OCT Measures.Translational vision science & technology · 2023Article
- Blood Pressure Measures and Incident Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2022Article
- Systemic Arterial Stiffness Is Associated With Structural Progression in Early Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2022Article
- Big data and electronic health records for glaucoma research.Taiwan journal of ophthalmologyReview
- Effect of Sleeping Position on the Retinal Nerve Fiber Layer in Individuals with Glaucoma.Journal of current glaucoma practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo investigate the effect of systemic arterial blood pressure (BP) on rates of progressive structural damage over time in glaucoma.
designRetrospective cohort study.
participantsA total of 7501 eyes of 3976 subjects with glaucoma or suspected of glaucoma followed over time from the Duke Glaucoma Registry.
methodsLinear mixed models were used to investigate the effects of BP on the rates of retinal nerve fiber layer (RNFL) loss from spectral-domain OCT (SD-OCT) over time. Models were adjusted for intraocular pressure (IOP), gender, race, diagnosis, central corneal thickness (CCT), follow-up time, and baseline disease severity.
main outcome measureEffect of mean arterial pressure (MAP), systolic arterial pressure (SAP), and diastolic arterial pressure (DAP) on rates of RNFL loss over time.
resultsA total of 157 291 BP visits, 45 408 IOP visits, and 30 238 SD-OCT visits were included. Mean rate of RNFL change was -0.70 μm/year (95% confidence interval, -0.72 to -0.67 μm/year). In univariable models, MAP, SAP, and DAP during follow-up were not significantly associated with rates of RNFL loss. However, when adjusted for mean IOP during follow-up, each 10 mmHg reduction in mean MAP (-0.06 μm/year; P = 0.007) and mean DAP (-0.08 μm/year; P < 0.001) but not SAP (-0.01 μm/year; P = 0.355) was associated with significantly faster rates of RNFL thickness change over time. The effect of the arterial pressure metrics remained significant after additional adjustment for baseline age, diagnosis, sex, race, follow-up time, disease severity, and corneal thickness.
conclusionsWhen adjusted for IOP, lower MAP and DAP during follow-up were significantly associated with faster rates of RNFL loss, suggesting that levels of systemic BP may be a significant factor in glaucoma progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.