Evidence map›Paper›PMID 34474060›Full record

ArticlePhysiology & behavior2021

Male HELLP pups experience sensorimotor delays and reduced body weight.

Ashley Griffin, Shauna-Kay Spencer, Teylor Bowles, Lucia Solis, Reanna Robinson, Sumana Ramarao, Kedra Wallace

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashley GriffinProgram in Neuroscience, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Shauna-Kay SpencerDepartment of Obstetrics and Gynecology, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Teylor BowlesDepartment of Obstetrics and Gynecology, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Lucia SolisDepartment of Obstetrics and Gynecology, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Reanna RobinsonDepartment of Obstetrics and Gynecology, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Sumana RamaraoDepartment of Pediatrics, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Kedra WallaceDepartment of Obstetrics and Gynecology, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States; Department of Neurobiology and Anatomical Sciences, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States. Electronic address: kwallace2@umc.edu.

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ashley C. Johnson, Babbette LaMarca · 2017 to 2026
$26.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Hypertension and Neuroinflammation during Pregnancy – The Impact on Maternal Behavior and Offspring NeurodevelopmentR01MH116027 · NIMH · UNIVERSITY OF MISSISSIPPI MED CTR · PI WALLACE, KEDRA L. · 2018 to 2019
$640k
NHLBI NIH HHS T32 HL105324NIGMS NIH HHS P20 GM121334NIMH NIH HHS R01 MH116027
6 · The paper itself

Abstract

Offspring of Preeclampsia (PreE) and HELLP Syndrome are at an increased risk of developing neurodevelopmental disorders. In the current study we sought to determine if offspring from experimental models of PreE and HELLP had evidence of early onset neurodevelopmental delay. Offspring from PreE, HELLP and normal pregnant dams were assessed in a battery of sensorimotor tests beginning on postnatal day (PND) 3. Male HELLP offspring showed altered behavior in the surface righting reflex on PND 3 and cliff avoidance task from PND 3-6 relative to other groups. Results suggest that there are sex differences in offspring born to dams with PreE and HELLP.

Indexed as

HELLP SyndromePrenatal Exposure Delayed EffectsBody WeightFemaleHumansMalePregnancyReflex, RightingBehaviorHELLPNeurodevelopmentOffspringPreeclampsiaSensorimotor

Identifiers

PMID34474060
PMCPMC8492499

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.