Trial reportPloS one2021
Consequences of using chronological age versus corrected age when testing cognitive and motor development in infancy and intelligence quotient at school age for children born preterm.
Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intelligence Quotient (IQ) in school-aged preterm infants: A systematic review.Frontiers in psychology · 2023Pooled it
- How Are Sleep, Settle, and Crying Behaviors in 2-Month-Olds Related to Concurrent Family Factors and Later Development?Developmental science · 2026Article
- Neurodevelopment at Two Years in Preterm Infants: Corrected Versus Chronological Age.Children (Basel, Switzerland) · 2026Article
- Preterm growth assessment: the latest findings on age correction.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Cognitive Competences in Preterm Infants across the First Year of Life: Assessments of Continuity, Stability, Coherence, Prediction, and Moderation by Infant Age and Country of Origin.International journal of behavioral development · 2025Article
- The qualitative motor assessment at three months allows a better prognosis than the traction test.Scientific reports · 2025Article
- Article
- Clinical superiority of artificial intelligence-enabled jaundice monitoring follow-up combined with end-tidal carbon monoxide measurement in neonatal jaundice management.American journal of translational research · 2025Article
- Investigation of the catch-up status and termination for corrected age of neurodevelopment in premature infants of different gestational ages.Translational pediatrics · 2024Article
- [Neurodevelopmental catch-up status and correction termination age in preterm infants of different gestational ages].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Visual attention and processing function in relation to executive functioning in very preterm-born children aged 3 years: a prospective cohort study.European journal of pediatrics · 2024Article
- Mathematics abilities associated with adaptive functioning in preschool children born preterm.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Article
- Influencing Factors on Independent Walking in Children With Lumbosacral Lipomas: A Retrospective Cohort Study Based on a 5-Year Untethering Series.Clinical medicine insights. Pediatrics · 2024Article
- Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring.Microbiome · 2023Article
- Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects.Acta pharmaceutica Sinica. B · 2023Article
- Sleep and 24-hour rhythm characteristics in preschool children born very preterm and full term.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Neurodevelopmental outcome of low-risk moderate to late preterm infants at 18 months.Frontiers in pediatrics · 2023Article
- Never-breastfed children face a higher risk of suboptimal cognition at 2 years of corrected age: A multinational cohort of very preterm children.Maternal & child nutrition · 2022Article
- Characteristics of Speech Sound Development in Preterm-Born Children: A Scoping Review.International journal of language & communication disordersReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren born preterm (<37 weeks' gestation) have an increased risk of poor neurodevelopment, including lower intelligence quotient (IQ) scores compared with their term-born counterparts.
objectiveTo explore the differences in psychometric scores for cognition and motor skills when they are age-standardized according to chronological age instead of corrected age for children born preterm.
methodsWe assessed = 554 children born <33 weeks' gestation with the Bayley Scales of Infant Development, 2nd edition (mental and motor scores) at 18 months and the Weschler Abbreviated Scale of Intelligence (IQ score) at seven years of age. Scores were standardized according to chronological age and corrected age and differences between mean chronological and corrected scores were compared, along with the proportion of children whose scores could be classified as impaired.
resultsWhen scores were standardized according to chronological age instead of corrected age there was a large significant difference of 17.3 points on the mental scale (79.5 vs. 96.8, respectively) and 11.8 points on the motor scale (84.8 vs. 96.6, respectively) at 18 months. By seven years, the difference in IQ scores remained, although of a smaller magnitude at 1.9 points between mean chronological and corrected age scoring (97.2 vs. 99.1, respectively).
conclusionConsistent with previous literature, outcome assessments for preterm infants consistently differed according to use of chronological or corrected age to standardized scores. Cognitive scores were impacted more severely than motor scores, and differences were more substantial in early childhood than later in childhood. For clinical purposes, correction for preterm birth is only likely to have an impact during early childhood, however assessments for research purposes should continue to correct into childhood to account for the persistent bias due to preterm birth.
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