Evidence map›Paper›PMID 34473740›Full record

Trial reportPloS one2021

Human placental perfusion measured using dynamic contrast enhancement MRI.

Benjamin Deloison, Chloé Arthuis, Gabriel Benchimol, Daniel Balvay, Laurence Bussieres, Anne-Elodie Millischer, David Grévent, Cécile Butor, Gihad Chalouhi, Houman Mahallati and 6 more

Registry-linked trialOpen access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01092949 (Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01092949 completednot on this map

Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2010 to 2018Enrolled135ConditionsPlacental InsufficiencyArmsMRI
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Magnetic resonance imaging of the monkey fetal brain in utero.Investigative magnetic resonance imaging · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Benjamin DeloisonService de Gynécologie-Obstétrique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Chloé ArthuisService de Gynécologie-Obstétrique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.ORCID 0000-0002-7937-3648
Gabriel BenchimolService de Gynécologie-Obstétrique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Daniel BalvayINSERM, U970, Paris Cardiovascular Research Center-PARCC, Sorbonne Paris Cité, Paris, France.
Laurence BussieresService de Gynécologie-Obstétrique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Anne-Elodie MillischerService de Radiologie, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
David GréventEA fetus 7328 and LUMIERE platform, Université Paris Descartes, Paris, France.
Cécile ButorEA fetus 7328 and LUMIERE platform, Université Paris Descartes, Paris, France.
Gihad ChalouhiService de Gynécologie-Obstétrique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.ORCID 0000-0002-3302-416X
Houman MahallatiService de Gynécologie-Obstétrique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Olivier HélénonService de Radiologie, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
Bertrand TavitianINSERM, U970, Paris Cardiovascular Research Center-PARCC, Sorbonne Paris Cité, Paris, France.ORCID 0000-0002-5349-8194
Olivier ClementINSERM, U970, Paris Cardiovascular Research Center-PARCC, Sorbonne Paris Cité, Paris, France.
Yves VilleService de Gynécologie-Obstétrique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Nathalie SiauveEA fetus 7328 and LUMIERE platform, Université Paris Descartes, Paris, France.
Laurent Julien SalomonService de Gynécologie-Obstétrique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Délégation Paris 5 · FRHôpital Necker-Enfants Malades · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and measure values of in vivo placental perfusion in women.

methodsThis study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses.

results134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA.

conclusionsMeasuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies.

Indexed as

Birth WeightPlacental CirculationChelating AgentsContrast MediaFeasibility StudiesFemaleFetal Growth RetardationGadoliniumGestational AgeHumansKaryotypeMagnetic Resonance ImagingPlacentaPregnancyChelating AgentsContrast MediaGadolinium

Identifiers

PMID34473740
PMCPMC8412340
OpenAlexW3197942517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.