Evidence map›Paper›PMID 34473738›Full record

SynthesisPloS one2021

The prevalence and clinical features of pulmonary embolism in patients with AE-COPD: A meta-analysis and systematic review.

Xiaofang Fu, Yonghong Zhong, Wucheng Xu, Jiangang Ju, Min Yu, Minjie Ge, Xiaofei Gu, Qingqing Chen, Yibo Sun, Huaqiong Huang and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  3. Observational
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  5. Review
  6. Article
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  14. Risk of Death and Cardiovascular Events Following an Exacerbation of COPD: The EXACOS-CV US Study.International journal of chronic obstructive pulmonary disease · 2024
    Article
  15. Observational
  16. Review
  17. Observational
  18. Observational
  19. Elevated Tissue Factor and TFPI Levels in Acute COPD Exacerbations: A Prospective Comparison With Stable COPD and Healthy Controls.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaofang FuDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Yonghong ZhongDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Wucheng XuDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Jiangang JuDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Min YuDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Minjie GeDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Xiaofei GuDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Qingqing ChenDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Yibo SunDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.
Huaqiong HuangKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Linfeng ShenDepartment of Respiratory, First People's Hospital of Yuhang, Hangzhou, China.ORCID 0000-0002-1350-6583
First People's Hospital of Yuhang District · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of pulmonary embolism (PE) in the acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) is highly controversial. We conducted a systematic review and meta-analysis to summarize the epidemiology and characteristics of PE with AE-COPD for current studies.

methodsWe searched the PubMed, EMBASE, Cochrane Library and Web of Science databases for studies published prior to October 21, 2020. Pooled proportions with 95% confidence intervals (95% CIs) were calculated using a random effects model. Odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals were used as effect measures for dichotomous and continuous variables, respectively.

resultsA total of 17 studies involving 3170 patients were included. The prevalence of PE and deep vein thrombosis (DVT) in AE-COPD patients was 17.2% (95% CI: 13.4%-21.3%) and 7.1% (95% CI: 3.7%-11.4%%), respectively. Dyspnea (OR = 6.77, 95% CI: 1.97-23.22), pleuritic chest pain (OR = 3.25, 95% CI: 2.06-5.12), lower limb asymmetry or edema (OR = 2.46, 95% CI:1.51-4.00), higher heart rates (MD = 20.51, 95% CI: 4.95-36.08), longer hospital stays (MD = 3.66, 95% CI: 3.01-4.31) were associated with the PE in the AE-COPD patients. Levels of D-dimer (MD = 1.51, 95% CI: 0.80-2.23), WBC counts (MD = 1.42, 95% CI: 0.14-2.70) were significantly higher and levels of PaO2 was lower (MD = -17.20, 95% CI: -33.94- -0.45, P<0.05) in the AE-COPD with PE group. The AE-COPD with PE group had increased risk of fatal outcome than the AE-COPD group (OR = 2.23, 95% CI: 1.43-3.50).

conclusionsThe prevalence of PE during AE-COPD varies considerably among the studies. AE-COPD patients with PE experienced an increased risk of death, especially among the ICU patients. Understanding the potential risk factors for PE may help clinicians identify AE-COPD patients at increased risk of PE. PROSPERO REGISTRATION NUMBER: CRD42021226568.

Indexed as

Acute DiseaseBiomarkersChest PainDyspneaFibrin Fibrinogen Degradation ProductsHumansLength of StayOdds RatioPrevalencePulmonary Disease, Chronic ObstructivePulmonary EdemaPulmonary EmbolismRisk FactorsVenous ThrombosisBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment D

Identifiers

PMID34473738
PMCPMC8412363
OpenAlexW3197973249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.