Evidence map›Paper›PMID 34473729›Full record

ArticlePloS one2021

Mutagenicity evaluation to UV filters of benzophenone-6, benzophenone-8, and 4-methylbenzylidene camphor by Ames test.

Jing Zhang, Zhou-Tao Pei, Ya-Ni Zhao, Meng Zhang, Li-Ling Zhang, Wen-Qiang Wang, Jing-Ya Wu, Ran Yu, Li-Wei Sun

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing ZhangSchool of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.
Zhou-Tao PeiSchool of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.
Ya-Ni ZhaoWater Pollution Control and Ecological Restoration Engineering Laboratory of Xizang, School of Information Engineering, Xizang Minzu University, Xianyang, China.
Meng ZhangSchool of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.
Li-Ling ZhangSchool of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.
Wen-Qiang WangSchool of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.
Jing-Ya WuSchool of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.
Ran YuSchool of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.
Li-Wei SunSchool of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.ORCID 0000-0002-8532-2687

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benzophenone (BPs) and 4-Methylbenzylidene Camphor are used as ultraviolet (UV) filters to protect the skin and hair in personal care products. The discharging of the three chemicals may endanger the receiving water ecosystem. In the present study, the mutagenicity of BP-6, BP-8, and 4-Methylbenzylidene Camphor was tested using the Salmonella typhimurium reverse mutation test (Ames test) in the system with and without rat liver microsomal preparations (S9). Four S.typhimurium strains, TA97, TA98, TA100, and TA102 were employed in the Ames tests. The mutagenicity was detected from all three chemicals. The addition of S9 increased the mutation ratios of three chemicals to four strains, except BP-6 to TA100 strain and 4-MBC to TA97 and TA98 strain. In the mixed experiment, all positive effects were detected in the absence of S9. However, the results all became negative in the presence of S9. For the mixture of BP-6 and 4-MBC, positive results were detected on four tester strains except for the TA100 strain. For the mixture of BP-6, BP-8, and 4-MBC, positive results were detected on four strains. The mixture test results showed antagonism in mutagenicity for the mixture of BP-6 and 4-MBC to TA98 and TA100 strains and the mixture of BP-6, BP-8, and 4-MBC to TA100 and TA102 strains.

Indexed as

AnimalsBenzophenonesBiological AssayCamphorEnvironmental MonitoringHumansMicrosomes, LiverMutagenesisMutagenicity TestsRatsSalmonella typhimuriumSunscreening AgentsUltraviolet RaysBenzophenonesCamphorenzacameneSunscreening Agents

Identifiers

PMID34473729
PMCPMC8412341

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.