Evidence map›Paper›PMID 34473725›Full record

ArticlePLoS neglected tropical diseases2021

A framework for scabies control.

Daniel Engelman, Michael Marks, Andrew C Steer, Abate Beshah, Gautam Biswas, Olivier Chosidow, Luc E Coffeng, Belen Lardizabal Dofitas, Wendemagegn Enbiale, Mosoka Fallah and 14 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06918665 (HEALTH Trial - Healthy Adult Evaluation of Ivermectin Bioequivalence), which is not on this map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06918665 phase1suspendednot on this mapstarted 2026, after this paper: background citation

HEALTH Trial - Healthy Adult Evaluation of Ivermectin Bioequivalence: Infant Versus Standard Formulation

TypeinterventionalSponsorMurdoch Childrens Research InstituteRan2026 to 2027Enrolled52ConditionsScabiesArmsivermectin infant formula preparation, Standard ivermectin 3mg tablet
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Prevalence and determinants of scabies: A global systematic review and meta-analysis.Tropical medicine & international health : TM & IH · 2024
    Pooled it
  3. Pooled it
  4. Mass Drug Administration for the Control of Scabies: A Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Pooled it
  5. Trial
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  13. Review
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  20. Crusted Scabies in a Malnourished Patient: A Rare Case Report.Clinical medicine insights. Case reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 19 institutions in 14 countries.

Daniel EngelmanTropical Diseases, Murdoch Children's Research Institute, Melbourne, Australia.ORCID 0000-0002-4909-1287
Michael MarksClinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0002-7585-4743
Andrew C SteerTropical Diseases, Murdoch Children's Research Institute, Melbourne, Australia.ORCID 0000-0001-7346-0196
Abate BeshahCommunicable Diseases, Neglected Tropical Diseases, WHO Regional Office for Africa, Brazzaville, Congo.ORCID 0000-0001-9627-349X
Gautam BiswasDepartment of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
Olivier ChosidowFaculté de Santé de Créteil et Service de Dermatologie, APHP, Hôpital Henri-Mondor, Université Paris-Est, Créteil, France.
Luc E CoffengDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0002-4425-2264
Belen Lardizabal DofitasCollege of Medicine, University of the Philippines, Manila, Philippines.ORCID 0000-0001-5494-9455
Wendemagegn EnbialeDepartment of Dermatovenerology, Bahir Dar University, Medicine and Health Science College, Addis Ababa, Ethiopia.ORCID 0000-0002-0692-850X
Mosoka FallahUniversity of Liberia, Monrovia, Liberia.
Elkhan GasimovDivision of Country Health Programmes, Malaria, Neglected Tropical Diseases and Other Vector-borne Diseases, WHO Regional Office for Europe, Copenhagen, Denmark.ORCID 0000-0003-0257-7682
Adrian HopkinsIndependent Consultant, United Kingdom.ORCID 0000-0002-3367-3231
Julie JacobsonBridges to Development, Seattle, Washington, United States of America.
John M KaldorPublic Health Interventions Research Group, Kirby Institute University of New South Wales, Sydney, Australia.
Fatimata LyDermatology Unit, EPS Institut d'Hygiéne Sociale de Dakar, Dakar, Senegal.
Charles D MackenzieTask Force for Global Health, Decatur, Georgia, United States of America.
Jodie McVernonPeter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.
Matthew ParnabyTropical Diseases, Murdoch Children's Research Institute, Melbourne, Australia.ORCID 0000-0002-7530-1620
Merelesita Rainima-QaniuciPacific Health Security & Communicable Diseases, Division of Pacific Technical Support, WHO, Suva, Fiji.ORCID 0000-0003-2197-2549
Oliver SokanaMinistry of Health, Honiara, Solomon Islands.
Dieudonne SankaraDepartment of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-2986-7631
Rie YotsuTulane School of Public Health and Tropical Medicine, New Orleans, United States of America.
Aya YajimaDivision of Communicable Diseases, Medicines, Vaccines and Pharmaceuticals, WHO Regional Office for the Western Pacific, Manila, Philippines.
Paul T CanteyDivision of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.ORCID 0000-0001-5290-6849
Royal Children's Hospital · AUWorld Health Organization · CHAmsterdam University Medical Centers · NLBuilding Bridges · USCenters for Disease Control and Prevention · USÉcole Nationale Vétérinaire d'Alfort · FRErasmus MC · NLHarvard University · USInstitut Pasteur de Dakar · SNLondon School of Hygiene & Tropical Medicine · GBThe Royal Melbourne Hospital · AUThe Task Force for Global Health · USTulane University · USUniversity of the Philippines Manila · PHUniversity of the South Pacific · FJUNSW Sydney · AUWorld Health Organization Regional Office for Africa · CGWorld Health Organization Regional Office for Europe · DKWorld Health Organization Regional Office for the Western Pacific · PH

Funding

World Health Organization 001
6 · The paper itself

Abstract

Scabies is a neglected tropical disease (NTD) that causes a significant health burden, particularly in disadvantaged communities and where there is overcrowding. There is emerging evidence that ivermectin-based mass drug administration (MDA) can reduce the prevalence of scabies in some settings, but evidence remains limited, and there are no formal guidelines to inform control efforts. An informal World Health Organization (WHO) consultation was organized to find agreement on strategies for global control. The consultation resulted in a framework for scabies control and recommendations for mapping of disease burden, delivery of interventions, and establishing monitoring and evaluation. Key operational research priorities were identified. This framework will allow countries to set control targets for scabies as part of national NTD strategic plans and develop control strategies using MDA for high-prevalence regions and outbreak situations. As further evidence and experience are collected and strategies are refined over time, formal guidelines can be developed. The control of scabies and the reduction of the health burden of scabies and associated conditions will be vital to achieving the targets set in WHO Roadmap for NTDs for 2021 to 2030 and the Sustainable Development Goals.

Indexed as

Public Health AdministrationAntiparasitic AgentsDelivery of Health CareDisease OutbreaksHumansIvermectinMass Drug AdministrationNeglected DiseasesPrevalenceResearchScabiesTropical MedicineVulnerable PopulationsAntiparasitic AgentsIvermectin

Identifiers

PMID34473725
PMCPMC8412357
OpenAlexW3198650614

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.