Evidence map›Paper›PMID 34473622›Full record

ArticleeLife2021

Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration.

Rene Solano Fonseca, Patrick Metang, Nathan Egge, Yingjian Liu, Kielen R Zuurbier, Karthigayini Sivaprakasam, Shawn Shirazi, Ashleigh Chuah, Sonja Lb Arneaud, Genevieve Konopka and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Rene Solano FonsecaDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-5927-5936
Patrick MetangDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Nathan EggeDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Yingjian LiuDepartment of Mechanical Engineering, University of Texas at Dallas, Dallas, United States.
Kielen R ZuurbierDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Karthigayini SivaprakasamO'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, United States.
Shawn ShiraziDepartment of Integrative Biology, University of California, Berkeley, Berkeley, United States.
Ashleigh ChuahDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Sonja Lb ArneaudDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-1123-3876
Genevieve KonopkaO'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-3363-7302
Dong QianDepartment of Mechanical Engineering, University of Texas at Dallas, Dallas, United States.
Peter M DouglasDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-0734-1049
The University of Texas Southwestern Medical Center · USThe University of Texas at Dallas · USUniversity of California, Berkeley · US

Funding

Heat Shock Factor mediates actin phosphorylation in tissue integrity and ageR01AG061338 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI DOUGLAS, PETER MAHAN · 2019 to 2023
$1.7M
Cell Non-Autonomous nature of the Heat Shock ResponseR00AG042495 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI DOUGLAS, PETER MAHAN · 2015 to 2017
$728k
Lipid sensing through small G protein prenylationR56AG070167 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI DOUGLAS, PETER MAHAN · 2021 to 2021
$336k
NIA NIH HHS R00 AG042495NIA NIH HHS R01 AG061338NIA NIH HHS R56 AG070167
6 · The paper itself

Abstract

Concussion is associated with a myriad of deleterious immediate and long-term consequences. Yet the molecular mechanisms and genetic targets promoting the selective vulnerability of different neural subtypes to dysfunction and degeneration remain unclear. Translating experimental models of blunt force trauma in

Indexed as

AstrocytesBrain Injuries, TraumaticNerve DegenerationAnimalsCaenorhabditis elegansCells, CulturedDopaminergic NeuronsGlycolysisHEK293 CellsHumansMiceNeuroprotectionastrocytesC. eleganscell biologymetabolismmitochondriamouseneurodegenerationneurosciencetraumatic brain injury

Identifiers

PMID34473622
PMCPMC8448530
OpenAlexW3197840181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.